Coexistence of High Fibrinogen and Low High-density Lipoprotein Cholesterol Levels Predicts Recurrent Cerebral Venous Thrombosis

Abstract

Background:Cerebral venous thrombosis (CVT) may lead to serious neurological disorders; however, little is known about the risk factors for recurrent CVT. Our aim was to determine the association between elevated fibrinogen and decreased high-density lipoprotein cholesterol (HDL-C) levels with recurrent CVT.Methods:This retrospective cohort study included participants if they had a first episode of objectively defined CVT and were admitted to Xuan Wu Hospital, Capital Medical University from August 2005 to September 2009. Demographic and clinical variables were collected, as well as laboratory parameters, including plasma fibrinogen and HDL-C. Patients with CVT were followed for recurrent symptomatic CVT. Follow-up was through the end of September 2010. Potential predictors of recurrence were analyzed using Cox survival analysis.Results:At the end of the follow-up, 95 patients were eligible for the study. Twelve of 95 patients (12.6%) had recurred CVT. The median time of recurrence was 7 months (range: 1–39 months). Eight of these 12 (66.7%) experienced recurrence within the first 12 months after their initial CVT. The recurrence rate of CVT was 2.76 per 100 patient-years. Multivariate Cox regression analysis demonstrated that the coexistence of high fibrinogen (>4.00 g/L) and low HDL-C (<1.08 mmol/L) levels at baseline was the only independent predictor for recurrent CVT (hazard ratio: 4.69; 95% confidence interval: 1.10–20.11; P < 0.05). Of the twelve patients with recurrent CVT in our study, 7 (58.3%) had high fibrinogen plus low HDL-C levels. All 7 of these patients took warfarin for 3–12 months, and 6 of 7 had recurrent CVT after the discontinuation of anticoagulant treatment.Conclusions:Concomitant high fibrinogen and low HDL-C levels may be associated with recurrence of CVT. The effect of potential risk factors related to atherothrombosis on recurrent CVT should be closely monitored.

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

“…Thrombosis, and therefore hypercoagulation, is typically associated with increased levels of fibrin(ogen) [ 58 , 70 , 71 ]. A changed iron profile (e.g.…”

Fibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction

“…A prior study by Ma et al [ 19 ] demonstrated a correlation between concurrent increases in FIB and declines in HDL levels and an increased risk of recurrent cerebral thrombosis, whereas the separate evaluation of FIB and HDL levels did not yield significant results. According to a study by Kowalski et al [ 30 ], the co-occurrence of elevated D-dimer, a breakdown product of FIB, and lower HDL levels appeared to contribute to the progression of acute pulmonary emboli.…”

“…Thus, despite the contrasting significance of FIB and HDL in relation to coagulation and inflammatory alterations, their combined role in mortality prediction among patients with AMI remains largely unexplored. To date, limited studies have explored the coexistence of elevated FIB values and decreased HDL that were associated with recurrent cerebral venous thrombosis (CVT) among those previously diagnosed with CVT [ 19 ]. Additionally, this combination was closely correlated with the onset of CVD among diabetes patients [ 20 ].…”

Blueberry Phenolics Reduce Gastrointestinal Infection of Patients with Cerebral Venous Thrombosis by Improving Depressant-Induced Autoimmune Disorder via miR-155-Mediated Brain-Derived Neurotrophic Factor

“…On the other hand, blueberry improves lipid profiles and can inhibit CVT development. Low level of HDL-C has been found to be associated with recurrence of CVT (Ma et al, 2015 ).…”