Coexistence of invasive ductal breast carcinoma and fibroadenoma

Saadallah, Fatma; Bouraoui, I; Naija, Lamia; Sakhri, Saida; Zemni, Inès; Hassouna, Jamel Ben; Dhieb, Tarak Ben; Bouzaiène, Hatem; Rahal, Khaled

doi:10.11604/pamj.2019.33.139.17140

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…Invasive ductal carcinoma (IDC) of the breast is the most common type of breast cancer and belongs to nonspecific invasive carcinoma of the breast. Clinically, patients often have breast lumps and nipple discharge [ 1 , 2 ]. IDC often affects the physical and psychological health of women due to the younger onset group, the tendency of lymphatic metastasis and recurrence in advanced patients, and the influence on the appearance of breasts after surgical resection [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features of 166 Cases of Invasive Ductal Breast Carcinoma and Effect of Primary Tumor Location on Prognosis after Modified Radical Mastectomy

Chen

Yang

2022

Emergency Medicine International

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Objective. To investigate the clinicopathological features of 166 cases of invasive ductal carcinoma (IDC) of the breast and to analyze the effect of the location of the primary tumor on the prognosis of modified radical mastectomy. Materials and Methods. The clinical data of 166 patients with IDC who underwent modified radical mastectomy in our hospital from May 2015 to May 2017 were retrospectively analyzed. The clinicopathological features of IDC patients were recorded. Univariate analysis and the multivariate logistic regression model were used to analyze the relationship between the location of the primary tumor and the prognosis of IDC patients after modified radical surgery. The effect of primary tumor location on the prognosis of modified radical resection was used with Survival curve analysis. Results. Among the patients in the central region, 13.33% had tumors >5 cm in diameter, which was higher than those in the other four groups. Among the patients in the upper inner quadrant, 59.38% received hormone therapy after operation, which was higher than those in the other four groups ( P < 0.05 ). There were no significant differences in age, menopause, histological grading, molecular typing, lymph node metastasis, vascular invasion, radiation therapy, and chemotherapy among different groups ( P > 0.05 ). Univariate analysis showed that molecular typing, lymph node metastasis, vascular invasion, and location of the primary tumor were all related to the prognosis of IDC patients after modified radical surgery, and the differences were statistically significant ( P < 0.05 ). Logistic regression analysis showed that molecular typing, lymph node metastasis, vascular invasion, and primary tumor location were all independent influencing factors for prognosis of IDC patients after modified radical surgery ( P < 0.05 ). As of 31 May 2021, there were 11 patients with recurrence and metastasis and 20 patients with death. The median survival time in the outer upper quadrant group was 80 months, which was higher than that in the outer lower quadrant group by 72 months, the median survival time in the central region group by 71 months, the median survival time in the inner upper quadrant group by 67 months, and the median survival time in the inner lower quadrant group by 61 months. The log-rank test showed all P < 0.001 . Conclusion. Patients with primary tumors located in the central area have larger tumor diameters. Patients located in the central area, upper inner quadrant, and lower inner quadrant are more likely to have lymphatic metastasis, have a more serious condition, and have a shorter prognosis survival time. Unluminal type, multiple lymph node metastases, vascular invasion, and the location of the primary tumor in the inner quadrant are all independent risk factors for prognosis in patients after modified radical surgery for IDC.

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Section: Introductionmentioning

confidence: 99%

Clinicopathological Features of 166 Cases of Invasive Ductal Breast Carcinoma and Effect of Primary Tumor Location on Prognosis after Modified Radical Mastectomy

Chen

Yang

2022

Emergency Medicine International

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“…Breast carcinoma may arise from a benign tumor or the tumors may coexist independently [ 4 ] Bilateral breast carcinomas are very rare and comprise only 2–5% of all breast malignancies with only triple-negative breast malignancies being rarer. About 2–11% of breast cancer patients will develop cancer in the opposite breast in their lifetime with an incidence rate varying from 4 to 8 per 1000 people per year.…”

Section: Discussionmentioning

confidence: 99%

Bilateral invasive ductal carcinoma of the breast; a case report with literature review

Hammood¹,

Najar

Latif³

et al. 2022

Annals of Medicine &Amp; Surgery

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“…Breast cancer (BC) ranks second in most frequent malignancies, accounting for 11.6% of new tumor cases and is the leading cause of cancer-related deaths in female 1,2 . Based on the histological structures and development process, breast cancer is broadly partitioned into invasive ductal carcinoma (IDC) and invasive lobular cancer (ILC) 3 , of which IDC is considered as the most challenging form occupying 80% of BC cases 4 .…”

Section: Introductionmentioning

confidence: 99%

LINC00092 Suppresses the Malignant Progression of Breast Invasive Ductal Carcinoma Through Modulating SFRP1 Expression by Sponging miR-1827

Zhao

et al. 2022

Cell Transplant

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Breast invasive ductal carcinoma (IDC) is a most common kind of breast cancer (BC), yet to date the corresponding effective therapies are limited. Extensive evidence has indicated that lncRNAs are involved in multiple cancers, and the potential mechanism of lncRNAs, such as LINC00092, mentioned in IDC remains elusive. IDC clinical samples from TCGA database were used to analyze the expression levels of LINC00092, miR-1827 and SFRP1. Kaplan-Meier method was applied to plot the overall survival curves. KEGG and GO were employed to screen the pathway that LINC00092 participated in. Pearson’s correlation analysis determined the relationship between LINC00092 and SFRP1. Bioinformatics analysis and dual-luciferase reporter assay examined the association among LINC00092, miR-1827, and SFRP1. Cell counting kit-8, colony formation and transwell assays were performed to detect cell viability, colony formation, and migration and invasion, respectively. Quantitative reverse-transcription polymerase chain reaction and western blot were utilized to investigate the expression at RNA and protein levels. LINC00092 expression was down-regulated in IDC tissues and cells, which was correlated with poor prognosis. Down-regulated LINC00092 facilitated cell proliferation, colony formation, and cell migration and invasion, while up-regulated LINC00092 inhibited cell malignant behaviors. LINC00092/SFRP1 physically bound to miR-1827 in IDC. SFRP1 expression was proportional to LINC00092 expression and inversely proportional to miR-1827 expression. The inhibitory effects of LINC00092 on cell aggressive behaviors were partially regulated by miR-1827/SFRP1. In summary, our results indicated that overexpression of LINC00092 inhibited the development of IDC through modulating miR-1827/SFRP1 axis, suggesting new therapeutic targets to treat IDC.

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Coexistence of invasive ductal breast carcinoma and fibroadenoma

Cited by 8 publications

References 11 publications

Clinicopathological Features of 166 Cases of Invasive Ductal Breast Carcinoma and Effect of Primary Tumor Location on Prognosis after Modified Radical Mastectomy

Clinicopathological Features of 166 Cases of Invasive Ductal Breast Carcinoma and Effect of Primary Tumor Location on Prognosis after Modified Radical Mastectomy

Bilateral invasive ductal carcinoma of the breast; a case report with literature review

LINC00092 Suppresses the Malignant Progression of Breast Invasive Ductal Carcinoma Through Modulating SFRP1 Expression by Sponging miR-1827

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