Coexistence of Leishmaniasis and Hodgkin's Lymphoma in a Lymph Node

Domingues, Mariana; Menezes, Yara; Ostronoff, Fabiana; Calixto, Rodolfo; Florêncio, Rodrigo; Sucupira, Alexandre; Souto-Maior, Ana Patricia; Ostronoff, M

doi:10.1200/jco.2009.22.7835

Cited by 13 publications

(15 citation statements)

References 12 publications

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“…VL can be an opportunistic infection in patients with malignancy, but the literature on malignancy and VL is restricted to case reports and small case series. Domingues et al [2009] described a 15-year-old Brazilian boy with Hodgkin´s Disease in his second remission when biopsy of an enlarged lymph node showed both Leishmania amastigotes and pathologic findings consistent with Hodgkin’s disease. Fakhar et al [2008] reported on a 12 year-old girl in Iran with acute lymphocytic leukemia and biopsy-confirmed VL.…”

Section: Visceral Leishmaniasis and Malignancymentioning

confidence: 99%

New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas

Dupnik

Nascimento

Rodrigues-Neto

et al. 2011

Drug Development Research

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Visceral leishmaniasis [VL] represents a major public health problem in many areas of the world. This review focuses on the impact of periurbanization on the epidemiology and treatment of VL, using Brazil as an example. VL continues to be mostly a disease of poverty with impact on families. However, the disease has expanded in Latin America, with foci reported as far south as Argentina. There is an increasing overlap of Leishmania infantum chagasi and HIV infections and other immunosuppressive conditions, resulting in VL emerging as an opportunistic infection. This new setting poses new challenges for VL disease control and patient management.

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Section: Visceral Leishmaniasis and Malignancymentioning

confidence: 99%

New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas

Dupnik

Nascimento

Rodrigues-Neto

et al. 2011

Drug Development Research

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“…The etiology of the disease is unknown, however, association with chronic immunosuppression including solid organ transplantation, hematopoietic neoplasms, inflammatory bowel disease, and malaria infection has been described [4]. Lymphomas of B-cell lineage have earlier been described in association with visceral leishmaniasis (VL) [5,6]. Also association of VL with hepatosplenic T-cell lymphoma has been reported in a canine in the past [7].…”

Section: Introductionmentioning

confidence: 99%

Hepatosplenic gamma delta T-cell lymphoma in a boy with visceral leishmaniasis: a case report

et al. 2013

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IntroductionHepatosplenic gamma delta T-cell lymphoma is a rare peripheral T-cell lymphoma of cytotoxic T-cell origin with an aggressive clinical course. Chronic immunosuppression has been proposed as a possible pathogenetic mechanism. No association of hepatosplenic gamma delta T-cell lymphoma with visceral leishmaniasis has been described in the past. We describe a case of an adolescent boy with hepatosplenic gamma delta T-cell lymphoma with leukemic presentation, who was diagnosed to have visceral leishmaniasis, 9 months prior to presentation at our center. To the best of our knowledge this is the first report of hepatosplenic gamma delta T-cell lymphoma with a prior history of visceral leishmaniasis in the medical literature.Case presentationA 13-year-old Indian boy presented to the hematology out-patient department with a history of progressive abdominal distension of 9 months’ duration and low grade fever of 2 months’ duration. He was a known case of visceral leishmaniasis and was treated with some clinical improvement in the past. However, his symptoms recurred and he was diagnosed to have hepatosplenic gamma delta T-cell lymphoma at our center. Cytogenetic analysis showed characteristic karyotype of isochromosome 7.ConclusionsChronic antigen stimulation due to visceral leishmaniasis may have led to an expansion of gamma delta T cells in our patient, and immunophenotypic analysis of bone marrow aspirate and characteristic karyotype helped to achieve the diagnosis. The aim of this case report is to highlight the rare association of hepatosplenic T-cell lymphoma with visceral leishmaniasis.

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“…Lymphadenopathies are however a rare finding in this entity 4. For proper diagnosis, direct visualisation of parasites on bone marrow smear or positive culture are required.…”

Section: Differential Diagnosismentioning

confidence: 99%

Fever and generalised lymphadenopathy in an HIV-positive patient: a diagnostic challenge

2017

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Fever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis.We present a 53-year-old male patient admitted with fever, weight loss of 15 kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells/mm3and viral load 3.172.370 copies/mL. A body CT scan showed multiple axillary, mediastinal, lumbar, aortic, iliac and pelvic lymphadenopathy as well as hepatosplenomegaly. An excisional biopsy of the left axillary lymphadenopathy was performed and histology ultimately revealed multicentric Castleman’s disease associated with Human Herpes Virus-8. After initiation of antiretroviral therapy, rituximab was given and progressive clinical improvement occurred.

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Coexistence of Leishmaniasis and Hodgkin's Lymphoma in a Lymph Node

Cited by 13 publications

References 12 publications

New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas

New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas

Hepatosplenic gamma delta T-cell lymphoma in a boy with visceral leishmaniasis: a case report

Fever and generalised lymphadenopathy in an HIV-positive patient: a diagnostic challenge

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