Coexistence of Membranous Glomerulonephritis and Kaposi’s Sarcoma: Case Report and Literature Review

Abstract

Kaposi's sarcoma (KS) is a malignant neoplasm of the vascular endothlium that closely related to human herpesvirus-8 (HHV-8) infection. Iatrogenic KS is associated with wide use of immunosuppressive therapy, which is well known in post-transplantation patient but only several cases reported in the literature associated with membranous glomerulonephritis. We herein report an unusual case of Kaposi's sarcoma in an HIV-negative patient with membranous glomerulonephritis from Sichuan, China. The 40-year-old male patient developed KS following treatment with long-term medium dose prednisolone, short-term cyclosporin and cyclophosphamide. The KS cases associated with glomerulonephritis are also reviewed.