High-temperature superconductivity emerges upon doping a state of matter that is insulating because of interactions. A widely studied model considers one orbital per CuO2 unit cell on a square lattice with a strong intra-orbital repulsion that leads to a so-called Mott-Hubbard insulator.Here we solve a model that takes into account, within each unit cell, two oxygen orbitals where there is no electron-electron repulsion and a copper orbital with strong electron-electron repulsion. The insulating phase is a so-called charge-transfer insulator, not a Mott-Hubbard insulator. Using cluster dynamical mean-field theory with continuous-time quantum Monte Carlo as an impurity solver and 12 atoms per cluster, we report the normal and superconducting phase diagram of this model as a function of doping, interaction strength and temperature. As expected, the three-orbital model is consistent with the experimental observation that doped holes are located predominantly on oxygens, a result that goes beyond the one-orbital model. Nevertheless, the phase boundary between pseudogap and correlated metal, the Widom line, and the origin of the pairing energy (kinetic vs potential) are similar to the one-orbital model, demonstrating that these are emergent phenomena characteristic of doped Mott insulators, independently of many microscopic details. Broader implications are discussed.The appearance of high-temperature superconductivity upon doping an interaction-driven insulator is one of the most surprising phenomena in nature. A major goal of research in that field is to chart the phase diagram in the hope of providing key insights into an unconventional pairing mechanism and into the nature of the strongly correlated states of matter observed. With experiments driving this quest, and revealing a complex phase diagram 1 , theory is challenged to provide a framework to explain such complexity. The challenge comes from the fact that the insulating phase that is doped arises from interactions so strong 2 that tools to describe such a nonperturbative regime are needed. Significant progress has been made in this area by novel theoretical approaches such as cluster extensions 3-5 of dynamical mean-field theory (DMFT) 6 .The physics that must be understood is that of a square lattice made of CuO 2 unit cells where electrons on copper interact strongly. Intense effort devoted to study the case of a single orbital per unit-cell with an on-site repulsion, i.e. the two-dimensional Hubbard model, has shown that this simple model captures the basic phenomenology of cuprates 7,8 . A more realistic model for the cuprates includes three orbitals per CuO 2 unit cell 9,10 . The necessity of this model is demonstrated by numerous experiments that show that doped holes are found on oxygen 11 . The ability to delocalize on oxygen allows electrons to feel a much weaker effective interaction, but at one-hole per unit-cell and strong-enough repulsion on copper, one obtains a charge-transfer insulator 12 . It is this kind of interactiondriven insulator of t...