Coexistence of Papillary and Medullary Thyroid Carcinoma: A Rare Entity

Synchronous Occurrence of Papillary Thyroid Carcinoma and Medullary Carcinoma in Hashimoto’s Thyroiditis and Multi Nodular Goiter Background

“…The management, treatment, and follow-up should be done accordingly. There is no difference between the biological behavior of MTC in association with PTC cases with solitary MTC cases (6).…”

“…The authors reported the frequencies of PTC and undifferentiated thyroid cancer were 6% and 2%, respectively, among all patients (14). The possibility of concurrence of HT, PTC, and MTC depends on some gene rearrangements (5,6,9,13). Besides these synchronous occurrences, HT has been introduced as playing a protective role against PTC progression (15).…”

“…The recovery rate in MTC is much lower than the other thyroid cancers. This carcinoma is the most aggressive type of thyroid cancer, and the rate of relapse and mortality is much higher than that in PTC (6).…”

“…Lymph node metastasis in the neck is over 75% of the large tumors and 50% of the small tumors. PTC has a high recovery rate and patients with PTC diagnosis have long-term prognoses (6).…”

Coexistence of Medullary and Papillary Thyroid Carcinomas Detected Incidentally

“…3 Coexistence of PTC and MTC is extremely rare, accounts for less than 0.5% of all thyroid malignancies. 4 Here, we report 8 cases of co-existing papillary and medullary thyroid carcinomas with histopathological features, imaging and laboratory findings, outcomes and impact of treatment with the data in the literature.…”