Coexistence of Takayasu’s Arteritis in Patients with Inflammatory Bowel Diseases

Abstract

Background. Takayasu’s arteritis (TA) and inflammatory bowel disease (IBD) are chronic inflammatory granulomatous disorders that have rarely been concomitantly reported in case reports and small case series. Objective. We report a series of seven cases of TA and IBD association in two referral centers with a comprehensive review of literature. Methods. We analyzed retrospectively the electronic medical charts of TA-IBD patients at the University Hospital of São Paulo, Brazil, and at the Sheba Medical Center at Tel Aviv University, Israel. Results. Overall, five patients had Crohn’s disease (DC) and two had ulcerative colitis (UC), and they were mostly female and non-Asian. All patients developed IBD first and, subsequently, TA. Two underwent colectomy and one ileocecectomy due to IBD activity, while three required cardiovascular surgery due to TA activity. Most patients are currently in clinical remission of both diseases with conventional drug treatment. Conclusion. Although the coexistence of TA and IBD is uncommon, both seem to be strongly associated through pathophysiological pathways.

Changes in Colonic Inflammation Related with Takayasu Arteritis during a 10-year Observation Period

“…Human lymphocyte antigen (HLA) B52 is known to be a common genetic background between TA and UC (3) but not between TA and CD. Akiyama et al reported that the endoscopic features of IBD complicated with TA at the initial diagnosis showed discontinuous and focal mucosal inflammations (87.5%), leading to a typical distribution of UC subsequently in many cases (4), and it was reported that many patients developed IBD first, followed by TA subsequently (10,11). These clinical characteristics and HLA type were all compatible with the present case.…”

A clinical case of early multifocal atherosclerosis complicated by acute coronary syndrome in a young man with ulcerative colitis

“…Миксоматозная дегенерация (система IL-33/ST2 может участвовать в развитии миксоматоза путем усиления ремоделирования внеклеточного матрикса) [35] Артериит Такаясу. Преимущественно у женщин с БК Генетические факторы риска: носительство человеческих лейкоцитарных антигенов HLA-A, HLA-B52, HLA-B35, HLA-DRB-1, HLA-DRB-2, обусловливаю щих совместно развитие ВЗК и артериита Такаясу [36] Примечание.…”