Coexistent atypical polypoid adenomyoma and endometrial adenocarcinoma

CD10 Immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium

“…However, we need to bear in mind the fact that cases of adenocarcinoma coexisting with APA have been reported, and this is an important topic [12][13][14][15][16]. The prognosis of most of these patients appeared to be favorable [13][14][15][16].…”

“…The prognosis of most of these patients appeared to be favorable [13][14][15][16]. On the other hand, Longacre et al [2] have expanded the concept of APA to lesions that contain glands that are sufficiently complex to satisfy the criteria for carcinoma, and they have termed such lesions as APA of low malignant potential.…”

Cytologic Features of Atypical Polypoid Adenomyoma of the Endometrium

“…6 Although most APAs appear to be benign, coexistent endometrial adenocarcinoma and the subsequent development of endometrial adenocarcinoma have been reported in some cases of APA of the endometrium. 4,7,8,10,11 Therefore, local excision accompanied by close follow-up should be mandatory as a treatment program. As most APAs occur in women of reproductive age, it is very important to obtain a cytologic and histologic diagnosis before surgery to conserve reproductive function.…”

Hysteroscopic treatment of atypical polypoid adenomyoma diagnosed incidentally in a young infertile woman

“…Although most cases are benign (3,5), APA has been occasionally found to coexist with or to precede the development of an endometrioid adenocarcinoma of the endometrium (EEC), which may be either within the APA or elsewhere in the uterus (6)(7)(8)(9). According to the data collected in a recent review of international literature, the average risk of EEC in women with APA is about 8.8%, which is considerably higher than the overall risk of 0.8% reported in women with endometrial polyps (10).…”

“…Indeed, while in postmenopausal women simple hysterectomy is the treatment of choice (6,7), in young women who wish to preserve their fertility, local resection and a careful postoperative follow-up might represent an appropriate treatment.…”