Coexistent Hypothyroidism and Idiopathic Thrombocytopenic Purpura

Volpe, Joseph A.; Johnston, Gerald S.

doi:10.1093/milmed/135.12.1146

Cited by 4 publications

(2 citation statements)

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“…The simultaneous development of two autoimmune disorders in a patient with an underlying autoimmune thyroiditis points to a possible common genetic factor among these three diseases. Further investigations into similar cases are needed to clarify this association [1][2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Concurrent immune thrombocytopenic purpura and Guillain‐Barre syndrome in a patient with Hashimoto's thyroiditis

Kohli

Bleibel

2007

American J Hematol

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Immune thrombocytopenic purpura (ITP), Guillain-Barre syndrome (GBS), and Hashimoto's thyroiditis (HT) are autoimmune disorders caused by impaired self-tolerance mechanisms triggered by interaction between genetic and environmental factors. ITP is an immune-mediated destruction of platelets resulting in mucocutaneous bleeding, GBS is an ascending motor paralysis caused by an inflammatory demyelination of peripheral nerves, and HT is characterized by autoimmune-mediated destruction of the thyroid gland. The concurrent development of ITP and GBS has only rarely been reported in the literature, and GBS itself rarely occurs with other autoimmune disorders. We present a 21 year-old patient with known Hashimoto's hypothyroidism that simultaneously developed GBS and ITP after an upper respiratory tract infection. To the best of our knowledge, this is the first reported case of these three autoimmune disorders in the same patient. This points to a possible common genetic predisposition to these disorders. Am. J. Hematol. 82:307-308, 2007. V V C 2006 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Concurrent immune thrombocytopenic purpura and Guillain‐Barre syndrome in a patient with Hashimoto's thyroiditis

Kohli

Bleibel

2007

American J Hematol

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“…[2] Even though autoimmune thrombocytopenia is an uncommon association with PAS, its association with PAS II and PAS III has been reported in several cases in the literature. [34567] The association of celiac disease with PAS is also reported in few case reports. [8910] It is quite interesting to note that the present case with PAS III is associated with empty sella and hypopituitarism, manifested by severe secondary adrenal insufficiency presenting with hypoglycemia, hyperprolactinemia and hypogonadism.…”

Section: Discussionmentioning

confidence: 98%

Polyglandular autoimmune syndrome iii with hypoglycemia and association with empty sella and hypopituitarism

Bokhari

Khan

Jabri

et al. 2017

Saudi J Med Med Sci

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A 25-year-old Saudi female with a known case of autoimmune thyroiditis presented to the Emergency Room in stuporous condition. A blood test revealed a blood sugar level of 1.7 mmols/l (30.6 mg/dl). The patient was resuscitated with intravenous glucose. Further evaluations of the patient revealed celiac disease and idiopathic thrombocytopenia with preexisting autoimmune thyroiditis (polyglandular autoimmune syndrome III [PAS III]). The severe hypoglycemia, coupled with 6 years of infertility evaluation, revealed a rare association of empty sella syndrome with hypopituitarism {PAS II}.

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