Coexisting brenner tumor and endometrial carcinoma

Sharma, Monica; Khangar, Babita; Mallya, Varuna; Khurana, Nita; Gupta, Sangeeta

doi:10.4103/jmh.jmh_3_17

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…About 7.5% of Brenner tumours are oestrogen-producing which increases the risk of EH or malignancy 13 14. Owing to its rarity, only case reports have been published regarding Brenner tumours and coexisting endometrial cancer 15 16. It is difficult to diagnose Brenner tumours on imaging 17.…”

Section: Discussionmentioning

confidence: 99%

Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system

Mok

Chin

2022

BMJ Case Rep

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Endometrial hyperplasia (EH) is a precursor of endometrial cancer. It arises in an environment of unopposed oestrogen. Treatment is based on a combination of weight management, diet and exercise, and the use of progestogens either via a levonogestrel-intrauterine system (LNG-IUS) or orally. The LNG-IUS is the first-line recommendation for EH without atypia. Recurrences are rare, and any recurrences despite prolonged treatment and control of risk factors necessitate a thorough consideration of other oestrogenic sources. This case report presents a rare case of a coexisting ovarian Brenner tumour and ovarian stromal hyperplasia in a menopausal patient in her 50s with recurrent EH despite earlier regression. The above histology may have provided the additional oestrogenic influence. This patient subsequently underwent a definitive hysterectomy and bilateral salpingo-oophorectomy (BSO). It is important to maintain a high index of suspicion for potential oestrogenic influences in cases of refractory EH that are not identifiable on imaging. BSO should be considered at the time of hysterectomy in such cases of unidentified oestrogenic foci.

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Section: Discussionmentioning

confidence: 99%

Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system

Mok

Chin

2022

BMJ Case Rep

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“…The presence of both epithelial and stromal components has been described as the features of Brenner tumors. Polygonal cells in clusters or single cells with moderately pleomorphic nuclei and multinucleate cells with variable mitotic figures revealed cytologic features of borderline or malignant Brenner tumors (11,14,15).…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma in an Ovarian Mass

Nazari¹,

Dehghani²

2020

Iran J Pathol

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Scan to discover online Ovarian cancer is the most lethal gynecologic malignancy. The surface epithelial tumor is the most common type of ovarian cancer. Among these, the mucinous tumors account for 10-15% of ovarian tumors. Mucinous ovarian tumors are among the most difficult ovarian neoplasms for surgical pathologists to interpret. Mucinous tumors sometimes coexist with other surface epithelial tumors. Therefore, making the accurate diagnosis of the mucinous tumors is essential. On the other hand, association of Brenner tumors with other neoplasms is rare. Ovarian Brenner tumor has always been discussed by pathologists as an enigmatic tumor, because of its rarity and disputed histogenesis. Here, we reported a case of large mucinous cystadenoma with Brenner component.

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“…The histopathology report was well-differentiated endometrioid carcinoma, Grade I with unilateral Brenner tumor. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

A rare case of grade 1 endometrioid adenocarcinoma of the uterus with omental metastasis with brenner tumor of the ovary in a postmenopausal female

et al. 2020

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Early-stage endometrial cancer may have microscopic omental metastases which is associated with a poor prognosis. There are no standard guidelines for omentectomy in early-stage endometrial cancer without risk factors. Brenner tumor is a rare ovarian tumor which is usually benign, but rarely, it may be malignant. Some Brenner tumors are endocrinologically active. Various studies have shown an association of Brenner tumor with endometrial hyperplasia, polyp, or early-stage carcinoma, probably due to its estrogen-secreting nature. We report a rare case of well-differentiated endometrioid adenocarcinoma of the uterus with <50% myometrial invasion with omental metastases associated with benign Brenner tumor of the ovary in a postmenopausal female.

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Coexisting brenner tumor and endometrial carcinoma

Cited by 8 publications

References 7 publications

Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system

Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system

Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma in an Ovarian Mass

A rare case of grade 1 endometrioid adenocarcinoma of the uterus with omental metastasis with brenner tumor of the ovary in a postmenopausal female

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