Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis

Fontenelle, Larry J.; Campbell, Donald J.

doi:10.1016/s0003-4975(10)65535-x

Cited by 14 publications

(11 citation statements)

References 7 publications

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“…Many researchers believe that scar tissue plays an important causative role in the development of lung cancer (9, 10); (B) As the reactivation of TB by carcinoma. It has also been reported that the development of lung cancer in areas of inactive TB stimulates the reactivation of tubercle bacilli (5, 11). In addition, the association between bronchogenic carcinoma and pulmonary TB may be related to increased susceptibility to opportunistic infections, which can lead to the reactivation of TB in cancer patients (12); (C) As coincidental.…”

Section: Discussionmentioning

confidence: 97%

“…Although the incidence of bronchogenic carcinoma in patients with active pulmonary TB has been reported as 5-6.4% (1, 4), these data are outdated, and to our knowledge, no report published during the era of CT has focused on this topic. Because the signs, symptoms, and radiologic findings can be masked by preexisting disease, a diagnosis of bronchogenic carcinoma superimposed on pulmonary TB is difficult (5). In most cases, the diagnosis of tumors in such patients is delayed, probably until an advanced stage.…”

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confidence: 99%

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Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

et al. 2001

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ObjectiveBronchogenic Carcinoma Can Mimic Or Be Masked By Pulmonary Tuberculosis (Tb), And The Aim Of This Study Was To Describe The Radiologic Findings And Clinical Significance Of Bronchogenic Carcinoma And Pulmonary Tb Which Coexist In The Same Lobe.Materials and MethodsThe findings of 51 patients (48 males and three females, aged 48-79 years) in whom pulmonary TB and bronchogenic carcinoma coexisted in the same lobe were analyzed. The morphologic characteristics of a tumor, such as its diameter and margin, the presence of calcification or cavitation, and mediastinal lymphadenopathy, as seen at CT, were retrospectively assessed, and the clinical stage of the lung cancer was also determined. Using the serial chest radiographs available for 21 patients, the possible causes of delay in the diagnosis of lung cancer were analyzed.ResultsLung cancers with coexisting pulmonary TB were located predominantly in the upper lobes (82.4%). The mean diameter of the mass was 5.3 cm, and most tumors (n=42, 82.4%) had a lobulated border. Calcification within the tumor was seen in 20 patients (39.2%), and cavitation in five (9.8%). Forty-two (82.4%) had mediastinal lymphadenopathy, and more than half the tumors (60.8%) were at an advanced stage [IIIB (n=11) or IV (n=20)]. The average delay in diagnosing lung cancer was 11.7 (range, 1-24) months, and the causes of this were failure to observe new nodules masked by coexisting stable TB lesions (n=8), misinterpretation of new lesions as aggravation of TB (n=5), misinterpretation of lung cancer as tuberculoma at initial radiography (n=4), masking of the nodule by an active TB lesion (n=3), and subtleness of the lesion (n=1).ConclusionMost cancers concurrent with TB are large, lobulated masses with mediastinal lymphadenopathy, indicating that the morphologic characteristics of lung cancer with coexisting pulmonary TB are similar to those of lung cancer without TB. The diagnosis of lung cancer is delayed mainly because of masking by a tuberculous lesion, and this suggests that in patients in whom a predominant or growing nodule is present and who show little improvement of symptoms despite antituberculous or other medical therapy, coexisting cancer should be suspected.

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Section: Discussionmentioning

confidence: 97%

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confidence: 99%

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

et al. 2001

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“…The reported incidence of pulmonary carcinoma accompanied with TB is 1%–2% and that of pulmonary TB accompanied with pulmonary carcinoma is 1%–5% [5]. Metastasis or intrinsic factors may activate or cause recurrence of the TB lesion [3]. Coexistence of TACW and lung cancer has rarely been reported.…”

Section: Discussionmentioning

confidence: 99%

A case report of tuberculous abscess of the chest wall accompanied with pulmonary carcinoma

Yukumi

Yamashita

Ichiki

et al. 2013

Respiratory Medicine Case Reports

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“…This is probably due to the efficiency of antituberculous drugs in increasing the number of patients who will live sufficiently long enough to develop a carcinoma. Deeley (1967) reported seventy-seven cases who had both lesions; other reports have been made by Bobrowitz et al (1961), Larmi (1967), Sherman, Conant & Peereboom (1967) and Fontenelle & Campbell (1970). Failure of a tuberculous lesion to respond to the appropriate antituberculous drugs should lead to further investigation, including sputum cytology, bronchoscopy and drill biopsy, if applicable, to determine whether there is an underlying carcinoma present also.…”

Section: Associated Diseasesmentioning

confidence: 99%

The early diagnosis of lung cancer

Deeley¹

1972

Postgraduate Medical Journal

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Summary Earlier diagnosis of malignant disease in the lung may bring about improvements in the treatment. This article discusses the effects of early diagnosis on the prognosis. Cancer of the lung may be associated with other lung pathology, thus increasing the problems of diagnosis. Diagnosis depends on radiological examination, cytology of the sputum, radio-isotope lung scanning and mediastinoscopy: an account is given of how these may be used to diagnose the condition whilst it is still at an early stage and suitable for radical treatment.

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Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis

Cited by 14 publications

References 7 publications

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

A case report of tuberculous abscess of the chest wall accompanied with pulmonary carcinoma

The early diagnosis of lung cancer

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