Coexisting carcinoma and active tuberculosis of the lung: 24 patients

Browne, M. J.; Healy, T. M.

doi:10.1007/bf02940150

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…According to researchers, any connection between active tuberculosis and malignancy is attributed to reactivation of infection in immunocompromised patients suffered from cancer rather than to a cause-and-effect relationship between infection and neoplasm [46][47][48]. Regarding Kaposi"s sarcoma association with tuberculosis, it has been hypothesized that constantly increased levels of circulating VEGF related to this pathogen might result in the carcinogenesis [45].…”

Section: Mechanism Of Tumorigenic Actionmentioning

confidence: 99%

Chronic bacterial and parasitic infections and cancer: a review

Samaras

Rafailidis

Mourtzoukou

et al. 2010

J Infect Dev Ctries

112

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Background: A relatively underestimated facet of infectious diseases is the association of chronic bacterial and parasitic infections with cancer development. Therefore, we sought to evaluate the evidence regarding the association of such infections with the development of malignancy, excluding the overwhelming evidence of the association of Helicobacter pylori and cancer. Methodology: We searched Pubmed, Cochrane, and Scopus without time limits for relevant articles. Results: There is evidence that some bacterial and parasitic infections are associated with cancer development. The level of evidence of this association varies from high to low; in any case, a long time interval is mandatory for the development of cancer. A high level of evidence exists for the association of Salmonella Typhi with gallbladder and hepatobiliary carcinoma; Opisthorchis viverrini and Clonorchis sinensis with cholangiocarcinoma; Schistosoma hematobium with bladder cancer; chronic osteomyelitis with squamous cell carcinoma of the skin; and hidradenitis suppurativa with squamous cell carcinoma of the skin. In contrast, the level of evidence regarding the association of Chlamydia spp. with cancer is low. Mycobacterium tuberculosis is associated with lung cancer, albeit probably not etiopathogenetically. Conclusions: A considerable number of bacterial infections and parasitic infections are associated with the development of cancer. Further research into recognizing additional associations of bacterial and parasitic infections with cancer is mandatory.

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Section: Mechanism Of Tumorigenic Actionmentioning

confidence: 99%

Chronic bacterial and parasitic infections and cancer: a review

Samaras

Rafailidis

Mourtzoukou

et al. 2010

J Infect Dev Ctries

112

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“…Furthermore, observed scars at tumor sites now appear to be the result of the malignancy rather than the cause. Any link between active tuberculosis and malignancy is currently ascribed to reactivation of infection in immunocompromised cancer patients rather than to a cause-and-effect relationship between infection and neoplasm (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Bacterial infection as a cause of cancer.

Parsonnet

1995

Environ Health Perspect

161

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Bacterial infections traditionally have not been considered major causes of cancer. Recently, however, bacteria have been linked to cancer by two mechanisms: induction of chronic inflammation and production of carcinogenic bacterial metabolites. The most specific example of the inflammatory mechanism of carcinogenesis is Helicobacter pylori infection. H. pylori has been epidemiologically linked to adenocarcinoma of the distal stomach by its propensity to cause lifelong inflammation. This inflammation is in turn thought to cause cancer by inducing cell proliferation and production of mutagenic free radicals and N-nitroso compounds. H. pylori is the first bacterium to be termed a definite cause of cancer in humans by the International Agency for Research on Cancer. Mutagenic bacterial metabolites are also suspected to increase risk for cancer. This model is best exemplified in colon cancer. Bile salt metabolites increase colonic cell proliferation. Exogenous compounds such as rutin may be metabolized into mutagens by resident colonic flora. Moreover, Bacteroides species can produce fecapentaenes, potent in vitro mutagens, in relatively high concentrations. In vivo data on human carcinogenesis by bacterial metabolites, however, are inconsistent. Local bacterial infections may also predispose to nonnodal lymphomas, although the mechanisms for this are unknown. Gastric lymphomas and immunoproliferative small intestinal disease have been most strongly linked to underlying bacterial infection. Because bacterial infections can be cured with antibiotics, identification of bacterial causes of malignancy could have important implications for cancer prevention. -Environ Health Perspect 1 03(Suppl 8): 263-268 (1995)

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“… 7 Similarly, other research believes any connection between active TB and malignancy is attributed to reactivation of infection in immune compromised patients suffering from cancer rather than to cause and effect relationship between infection and neoplasm. 8 …”

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confidence: 99%