Coexisting Metastatic Choriocarcinoma and Normal Pregnancy

Hutchison,; Ep, Peterson; Ea, Zimmermann

doi:10.1097/00006250-196803000-00005

Cited by 16 publications

(5 citation statements)

References 0 publications

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“…In the case described by Nabers, the treatment was started at the 27th week of gestation, in the other two cases at the 30th week. One infant ( 25 ) had transient seizures and a unilateral talipes equinovarus but eventually developed normally. The other two infants did not show significant handicaps or malformation.…”

Section: Review Of the Literaturesupporting

confidence: 88%

“…The cases described by Hutchinson ( 25 ) , Naber ( 51 ) and Gangadharan ( 62 ) are particularly interesting, as the fetus was delivered after treatment of the mother. In the case described by Nabers, the treatment was started at the 27th week of gestation, in the other two cases at the 30th week.…”

Section: Review Of the Literaturesupporting

confidence: 73%

“…Since 1968, four reports have discussed the use of chemotherapy during pregnancy ( 25 , 51 , 62 ) (see also our first case). In three cases the fetus was sufficiently developed to withstand the treatment in utero and the patients delivered a living and apparently healthy infant.…”

Section: Discussionmentioning

confidence: 99%

“…In nine additional cases it could be documented in the uterus. In some cases the placenta was not evaluated and in a further three ( 25 , 51 , 62 ) no tumor was found in the placenta after chemotherapy. In no case was metastatic spread documented in the fetus or in the new‐born.…”

Section: Review Of the Literaturementioning

confidence: 99%

“…However, the diagnosis of choriocarcinoma within 6 months after delivery is relatively common, whereas the diagnosis of choriocarcinoma in a woman with a normal intrauterine pregnancy remains extremely rare. Even more extraordinary is the diagnosis of metastatic choriocarcinoma in a fetus or in an infant ( 2 –62 ) .…”

mentioning

confidence: 99%

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Choriocarcinoma coexistent with intrauterine pregnancy: two additional cases and a review of the literature

Zanetta¹,

Maggi²,

Colombo³

et al. 1997

Int J Gynecol Cancer

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Choriocarcinoma coexistent with normal intrauterine pregnancy is rare and poses questions about its origin. Although the development from trophoblastic remnants of previous pregnancies can not be excluded in some cases, the findings of incidental macro- and microscopic foci of choriocarcinoma in apparently normal placentas show the possible transformation of normal trophoblast into choriocarcinoma during an otherwise normal pregnancy. The diagnosis and management of choriocarcinoma coexistent with intrauterine pregnancy have changed dramatically over the decades but the survival rates are still unsatisfactory. In this review, we summarize some of the most common features of this disease.

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Section: Review Of the Literaturesupporting

confidence: 88%

Section: Review Of the Literaturesupporting

confidence: 73%