Coextraction during reactive extraction of phenylalanine using Aliquat 336: Modeling extraction equilibrium

Abstract

Reactive liquid-liquid extraction can be used to recover hydrophilic fermentation products that would not otherwise partition into nonpolar solvents through an ion-exchange reaction at the two-phase interface. However, the ion-exchange reagent may not be specific to the solute of interest and other compounds present may also be extracted. In this study, the effect on solute extraction of other compounds present in the extraction medium was investigated for phenylalanine extraction using Aliquat 336. The extent of extraction at equilibrium was modeled using the equilibrium constants for the reactions present in the process. The interaction of different species within a multicomponent medium was examined using the model and experimental results. It was found that the extent of extraction and coextraction is controlled by the thermodynamics of each extraction reaction and, due to the formation of a common product, the interaction between each of the reactions. The main competition to reactive extraction will come from hydrophobic anionic compounds that will be present in fermentation broth.

Effect of fermentation broth and biosurfactants on mass transfer during liquid–liquid extraction

“…Extraction equilibrium experiments were performed using a mixer settler technique that has been described elsewhere (Pursell et al, 2002a).…”

Cutting Long Syntheses Short: Access to Non‐Natural Tyrosine Derivatives Employing an Engineered Tyrosine Phenol Lyase

“…[7] The classical synthetic route for these tyrosine derivatives usually comprises several steps including protection and deprotection of the functional amino acid groups making it very laborious and time-consuming. [1,8,9] Our aim was to evaluate chemical and biocatalytic options for the preparation of optically enriched 3-substituted tyrosine derivatives.…”

Reactive extraction of N-acetylneuraminic acid—A new method to recover neuraminic acid from reaction solutions

“…Usually, equilibrium constants for an extraction are determined from a plot of [ [28]. This is not possible with the PBA reaction prior to extraction because the concentration of the carbohydrate-PBA complex in the aqueous phase cannot be determined.…”