Cofactors in human papillomavirus infection and cervical carcinogenesis

Yetimalar, Hakan; Kasap, Burcu; Çukurova, Külal; Yildiz, Aşkın; Keklik, Adnan; Soylu, Ferit

doi:10.1007/s00404-011-2034-3

Cited by 24 publications

(23 citation statements)

References 31 publications

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“…A consistent critical role of HPV infection in the causation of cervical cancer has been identified and well accepted (Guan et al, 2012), and cigarette smoking was deemed as a cofactor that raised the possibility and promoted progression of cervical carcinogenesis (Winkelstein, 1990;Yetimalar et al, 2012). For both active and passive smoking have similar function inducing proinflammatory responses by influencing C-respone protein (Azar et al, 2011), and combined effects of exposure to active and passive smoking suggest its potential a increase risk factor of cervical cancer, however, passive smoking could not be detected as an independent risk factor of cervical cancer when lack of active smoking (Louie et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases and 2,982 Controls

Zeng¹,

Xiong²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: Passive smoking has been considered as a risk factor of many cancers. To examine whether it might also pose a risk for cervical cancer, we performed a meta-analysis based on published case-control studies. Methods: We searched the PubMed database and references of included studies up to February 10th, 2012 for relevant studies. After two authors independently assessed the methodological quality and extracted data, a meta-analysis was conducted using CMA v2 software. Publication bias was evaluated by funnel plot, using Egger's and Begg's tests. Results: Finally 11 eligible studies yielded, involving 3,230 cases and 2,982 controls. The results showed that women who never smoke but exposed to smoking experience a 73% increase in risk of cervical cancer compared with non-exposed women (OR = 1.73, 95% CI = 1.35 -2.21, p<0.001). Subgroup and sensitivity analyses indicated this result to be robust. Moderate publication bias was detected by visualing funnel plot, Egger's and Begg's tests. Conclusion: Based on currently available evidence, the findings of this meta-analysis suggests that passive smoking significantly and independently increases the risk of cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases and 2,982 Controls

Zeng¹,

Xiong²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Smoking exposure-a welldocumented environmental factor-is a leading cause of many types of cancer such as lung, esophageal, gastric, bladder, liver and cervical cancers (Tredaniel et al, 1997;Kinjo et al, 1998;Gallus et al, 2001;Sobue et al, 2002 ;Settheetham-Ishida et al, 2004;Samanic et al, 2006;Settheetham-Ishida et al, 2006;Syrjanen et al, 2007;Pesch et al, 2011). An increased risk of cervical cancer associated with tobacco smoking has been found in many studies (Haverkos et al, 2003;SettheethamIshida et al, 2004;Garland et al, 2011;Yetimalar et al, 2011). Among HPV-positive women, an increased risk of cervical cancer was demonstrated among smokers than non-smokers (Kapeu et al, 2009;Plummer et al, 2003).…”

Section: Introductionmentioning

confidence: 96%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97 (p<0.001) and an adjusted OR of 38.07 (p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78 (p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36 (p<0.001) and 2.17 (p<0.05); and respective adjusted ORs of 2.90 (p<0.05) and 3.55 (p<0.05). Other smoking characteristics of the partners including smoking duration ≥ 20 years, number of cigarettes smokes ≥ 20 pack-years and exposure time of the subject to passive smoking ≥ 5 hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

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“…Yetimalar ve ark. HPV pozitifliği için risk faktörü olan 642 hastalık, yaş ortalaması 36±9 olan çalışmalarında, HPV DNA pozitifliğini multipleks PCR yöntemiyle %39 olarak saptamışlar (14). Eroğlu ve ark.…”

Section: Discussionunclassified

“…Erken seksüel yaşama başlanmasının duyarlı transformasyon zonunun genişliği nedeniyle HPV enfeksiyonuna zemin hazırladığı bilinmektedir (14). Bizim çalışmamız bu bilgiye aykırı bir sonuç sunmakta.…”

Section: Discussionunclassified

Kronik Vajinal Akıntılı Hastalarda HPV-DNA Pozitiflik Oranı ve Sitopatolojik Sonuçların Değerlendirilmesi

Ateşer¹,

Aydın²,

Gunver³

et al. 2014

Haseki

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Abs tractAim: There are new publications stating that chronic infection may facilitate dysplastic changes and persistence of human papillomavirus (HPV)-DNA positivity. Frequency of this coincidence and cervical cytological and pathological examination results were investigated in patients with chronic vaginal discharge. Methods: One hundred three patients, who were treated at least 3 times for chronic mucopurulent discharge with accessible HPV DNA results, were analyzed retrospectively. Risk factors were identified for HPV DNA positivity. HPV DNA positive-patients were divided into two groups (positive and negative) according to the presence and absence of HPV DNA. The results of cytopatological and histopathological examinations and risk factors were compared between the two groups. Results: The mean age of the patients was 35±9 years. Sixty-four percent of the patients were positive for HPV DNA. Of the HPV DNA positive patients, 41% had abnormal cytological findings, 16% had cervical intraepithelial neoplasia (CIN). Of the HPV DNAnegative patients, 16% had abnormal cytological findings and, 2 patients had CIN. There was no statistically significant difference in cervical cytological abnormalities and CIN between HPV-DNA positive and negative groups. Conclusion: In our study, the rates of HPV DNA positivity and abnormal cytopathological results among patients with chronic vaginal discharge were found to be higher than that reported in the literature.

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Cofactors in human papillomavirus infection and cervical carcinogenesis

Cited by 24 publications

References 31 publications

Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases and 2,982 Controls

Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases and 2,982 Controls

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Kronik Vajinal Akıntılı Hastalarda HPV-DNA Pozitiflik Oranı ve Sitopatolojik Sonuçların Değerlendirilmesi

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