CoFe₂O₄ Nanoparticles as a Magnetically Recoverable and Reusable Catalyst for the Synthesis of Arylaminotetrazoles and 5-aryloxytetrazoles

Abstract

An efficient and direct method is described for the synthesis of 5-arylamino-1H-tetrazoles (Isomer A) or 1-aryl-5-amino-1Htetrazoles (Isomer B) and 5-aryloxytetrazoles from arylcyanamides or cynates with nano CoFe 2 O 4 as a reusable and efficient heterogeneous catalyst. Isomer A was obtained from arylcyanamides carrying electron-withdrawing substituents on the aryl ring, while isomer B was produced with electron-releasing groups. The significant advantages of this methodology are high yields, elimination of dangerous and harmful hydrazoic acid, simple work-up procedure and the recovery and reusability of the catalyst.

Magnetically Separable Transition Metal Ferrites: Versatile Heterogeneous Nano‐Catalysts for the Synthesis of Diverse Bioactive Heterocycles

“…A series of 5‐aryloxytetrazoles ( 10 ) was synthesized by Bahari et al . (Table ) via the click reaction between arylcynates ( 8 ) and sodium azide ( 9 ) using a catalytic amount of nano‐CoFe 2 O 4 as an efficient heterogeneous catalyst in dimethyl formamide at 110 °C. Under the same reaction conditions a series of 1‐aryl‐5‐amino‐1 H ‐tetrazoles ( 12 ) or 5‐arylamino‐1 H ‐tetrazoles ( 13 ) was also synthesized by replacing arylcynates ( 8 ) with arylcyanamides ( 11 ) having electron‐donating or electron‐withdrawing substituent respectively on the aryl ring (Scheme ).…”

Comparative Study of CuO, Fe3O4 and CuFe2O4/CuO over Montmorillonite Clay: Green Synthesis, Characterization and Catalytic Activity

“…[24] To date, diverse heterogeneous catalysts were synthesized and scrutinized for the synthesis of aminotetrazole derivatives. [25,26,35,[27][28][29][30][31][32][33][34] Despite the advantages of the these reported methods, there is still a need to explore effective methods and improve the synthesis of aminotetrazole using new strategies and catalysts, due to the vital importance of these class of compounds in synthetic chemistry and pharmaceutical research applications.…”