Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway

Chiang, Hsiu-Mei; Lin, Tsen-Jung; Chiu, Chen‐Yuan; Chang, Chiung‐Wen; Hsu, Kuo-Chiu; Fan, Pei-Ching; Wen, Kuo‐Ching

doi:10.1016/j.fct.2010.10.034

Cited by 106 publications

(111 citation statements)

References 41 publications

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“…In this study, three poly-phenols, including chlorogenic acid, ferulic acid and rutin, were identified as the predominant active compounds in FV. Chlorogenic acid were reported to prevent photoaging by suppressing MMP expression through MAP kinase pathway (Chiang et al, 2011). There are also reports about ferulic acid and rutin on inhibition of UVB-induced matrix metalloproteinases in mouse skin (Staniforth et al, 2012), (Hwang et al, 2014).…”

Section: Accepted Manuscriptmentioning

confidence: 97%

Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways

et al. 2016

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Section: Accepted Manuscriptmentioning

confidence: 97%

Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways

et al. 2016

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“…14) In the past decade, a number of papers have reported the isolation of MMP-1 inhibitors from plant resources. Examples include aucubin from Eucommia ulmoides cortex, 15) tectoridin-4′-O-β-D-glucoside from aerial parts of Viola hondoensis, 16) sumaflavone and amentoflavone from whole plant of Selaginella tamariscina, 17) styraxjaponoside B and erythrodiol-3-acetate from Styrax japonica stem, 18,19) xanthorrhizol from Curcuma xanthorrhiza rhizome, 14) caffeic acid and chlorogenic acid from Coffea arabica leaf, 20) panduratin A and 4-hydroxypanduratin A from Kaempferia pandurata rhizome, 21,22) Punica granatum extract, 23) Emblica officinalis extract 24) and Sanguisorba officinalis extract. 25) Among these plants, a few plant such as Coffea arabica leaf extract 20) is known to have HLE inhibitory activity.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-1 Inhibitory Activities of Morinda citrifolia Seed Extract and Its Constituents in UVA-Irradiated Human Dermal Fibroblasts

Masuda

Murata

Naruto

et al. 2012

Biological & Pharmaceutical Bulletin

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The objective of this study was to examine whether a 50% ethanolic extract (MCS-ext) of the seeds of Morinda citrifolia (noni) and its constituents have matrix metalloproteinase-1 (MMP-1) inhibitory activity in UVA-irradiated normal human dermal fibroblasts (NHDFs). The MCS-ext (10 μg/mL) inhibited MMP-1 secretion from UVA-irradiated NHDFs, without cytotoxic effects, at 48 h after UV exposure. The ethyl acetatesoluble fraction of MCS-ext was the most potent inhibitor of MMP-1 secretion. Among the constituents of the fraction, a lignan, 3,3′-bisdemethylpinoresinol (1), inhibited the MMP-1 secretion at a concentration of 0.3 μM without cytotoxic effects. Furthermore, 1 (0.3 μM) reduced the level of intracellular MMP-1 expression. Other constituents, namely americanin A (2), quercetin (3) and ursolic acid (4), were inactive. To elucidate inhibition mechanisms of MMP-1 expression and secretion, the effect of 1 on mitogen-activated protein kinases (MAPKs) phosphorylation was examined. Western blot analysis revealed that 1 (0.3 μM) reduced the phosphorylations of p38 and c-Jun-N-terminal kinase (JNK). These results suggested that 1 suppresses intracellular MMP-1 expression, and consequent secretion from UVA-irradiated NHDFs, by down-regulation of MAPKs phosphorylation.Key words Morinda citrifolia; noni seed; matrix metalloproteinase-1 inhibitor; photoaging; 3,3′-bisdemethylpinoresinol Normal human dermis primarily consists of an extracellular matrix of connective tissue, of which the most abundant protein is collagen. Chronic UV exposure denatures collagen and elastic fibers in the dermis and induces wrinkles, thereby promoting photoaging.1) UV induces the production of matrix metalloproteinases (MMPs) by activating intracellular signal transcription pathways, including mitogen-activated protein kinase (MAPK) p38 and c-Jun-N-terminal kinase (JNK). 2)Activation of the phosphorylation of MAPKs may lead to an over expression of c-Jun and c-Fos. This results in induction of activator protein-1 (AP-1), which, in turn, up-regulates expression of MMPs.3) MMPs are a family of structurally related matrix degrading enzymes that are associated with various destructive processes, including inflammation, tumor invasion and skin aging.1) MMPs are subdivided in different types at least over 20 members.4) Among them, MMP-1, secreted from human skin fibroblasts, is mainly responsible for the degradation of dermal collagen in the photoaging process of human skin.5) Neutrophils play an important role during the process of photoaging, which are set in motion by UV irradiation. The neutrophils infiltrate into the skin and release several active enzymes, such as MMPs and human leukocyte elastase (HLE).6) HLE cleaves the helix structure of type I collagen and then degrades elastic fiber in human skin. 7) HLE also directly activates MMP-1 from human dermal fibroblasts. 8)Thus, it is expected that MMP-1 inhibitors and/or HLE inhibitors may be useful for the prevention of photoaging of human skin.Morinda citrifolia L. (Rubiaceae), commonly kno...

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“…The production of spent coffee extracts is a profitable way to valorise this by-product. Currently, spent coffee extracts may be used as ingredients in the energy food segment and the cosmeceutical industry due to their content in caffeine and also the chlorogenic acids properties for preventing anticellulite (Dück et al, 2009) and preventing skin photoaging (Chiang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Valorisation of spent coffee through membrane processing

Brazinha

Cadima

Crespo

2015

Journal of Food Engineering

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Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway

Cited by 106 publications

References 41 publications

Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways

Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways

Matrix Metalloproteinase-1 Inhibitory Activities of Morinda citrifolia Seed Extract and Its Constituents in UVA-Irradiated Human Dermal Fibroblasts

Valorisation of spent coffee through membrane processing

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