Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine

Johnston, Kelly L.; Clifford, Michael N.; Morgan, Linda

doi:10.1093/ajcn/78.4.728

Cited by 524 publications

(380 citation statements)

References 26 publications

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“…Although the mechanism by which the hydroxycinnamic acids prevent oxidative stress are not yet fully elucidated, it seems to be mediated by translocation of Bad from the cytosol to the mitochondria where it dimerizes with Bcl-2 and Bcl-XL thereby neutralizing their mitochondrial stabilizing effect (Johnston, Clifford & Morgan, 2003). Chlorogenic acids may prevent oxidative stress induced mitochondrial transition pore complex opening by decreasing production of Bax and Bak protein, favoring an increase in Bcl2-BclXL/Bax-Bak ratio (Johnston et al 2003).…”

Section: Antioxidant Activity Of Hydroxycinnamic Acidsmentioning

confidence: 99%

“…Chlorogenic acids may prevent oxidative stress induced mitochondrial transition pore complex opening by decreasing production of Bax and Bak protein, favoring an increase in Bcl2-BclXL/Bax-Bak ratio (Johnston et al 2003).…”

Section: Antioxidant Activity Of Hydroxycinnamic Acidsmentioning

confidence: 99%

“…The presence of phenolic compounds in plants has been studied by participating in processes responsible for color, astringency and flavoring in different foods. Furthermore, due to their antioxidant activity, several researchers have attributed a probable role of these compounds in preventing of various diseases associated with oxidative stress, such as cancer and cardiovascular and neurodegenerative diseases (Manach et al, 2004;Johnston, Clifford, & Morgan, 2003;Natella, Nardini, Giannetti, Dattilo & Scaccini, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Properties of Hydroxycinnamic Acids -A Review

Rocha¹,

Monteiro²,

Teodoro

2012

CCO

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Hydroxycinnamic acid compounds are an important source of antioxidants due to their ubiquitous occurrence in the plant kingdom and their characteristic activities. Due to their antioxidant activity, several researchers have attributed a probable role of these compounds in the prevention of various diseases associated with oxidative stress, such as cancer and cardiovascular diseases. Recent evidence suggests that these compounds may also act by other mechanisms in addition to the antioxidant capacity as modulating the activity of some specific enzymes and inhibit cell proliferation. This paper is a comprehensive review of the effects of hydroxycinnamic acids on cancer. The review encompasses the occurrence and bioavailability of these compounds evidences for their effects on cancer and the various mechanisms by which may exert their effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis; effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.

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Section: Antioxidant Activity Of Hydroxycinnamic Acidsmentioning

confidence: 99%

Section: Antioxidant Activity Of Hydroxycinnamic Acidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anticancer Properties of Hydroxycinnamic Acids -A Review

Rocha¹,

Monteiro²,

Teodoro

2012

CCO

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“…Chlorogenic acid also acts as a competitive inhibitor of glucose absorption in the intestine (8,35). Indeed, decaffeinated coffee seemed to delay intestinal absorption of glucose and increased glucagon-like peptide 1 concentrations in an intervention study in humans (8,36). Glucagon-like peptide 1 is well known for its beneficial effects on glucoseinduced insulin secretion and insulin action (8,37).…”

mentioning

confidence: 99%

Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey

Choi

Curhan

2007

Arthritis & Rheumatism

211

122

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Objective. Coffee is one of the most widely consumed beverages in the world and may affect serum uric acid levels and risk of gout via various mechanisms. Our objective was to evaluate the relationship between coffee, tea, and caffeine intake and serum uric acid level in a nationally representative sample of men and women. Methods. Using data from 14,758 participants ages >20 years in the Third National Health and Nutrition Examination Survey (1988 -1994), we examined the relationship between coffee, tea, and caffeine intake and serum uric acid level using linear regression. Additionally, we examined the relationship with hyperuricemia (serum uric acid >7.0 mg/dl among men and >5.7 mg/dl among women) using logistic regression. Intake was assessed by a food frequency questionnaire. Results. Serum uric acid level decreased with increasing coffee intake. After adjusting for age and sex, serum uric acid level associated with coffee intake of 4 to 5 and >6 cups daily was lower than that associated with no intake by 0.26 mg/dl (95% confidence interval [95% CI] 0.11, 0.41) and 0.43 mg/dl (95% CI 0.23, 0.65; P for trend < 0.001), respectively. After adjusting for other covariates, the differences remained significant (P for trend < 0.001). Similarly, there was a modest inverse association between decaffeinated coffee intake and serum uric acid levels (multivariate P for trend 0.035). Total caffeine from coffee and other beverages and tea intake were not associated with serum uric acid levels (multivariate P for trend 0.15). The multivariate odds ratio for hyperuricemia in individuals with coffee intake >6 cups daily compared with those with no coffee use was 0.57 (95% CI 0.35, 0.94; P for trend 0.001). Conclusion. These findings from a nationally representative sample of US adults suggest that coffee consumption is associated with lower serum uric acid level and hyperuricemia frequency, but tea consumption is not. The inverse association with coffee appears to be via components of coffee other than caffeine.

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“…Di dalam kopi, terdapat senyawa polifenol yang telah dikenal sebagai senyawa antioksidan yang dapat melawan radikal bebas. Menurut beberapa hasil penelitian, mengkonsumsi kopi dapat menurunkan insiden dari berbagai macam penyakit diantaranya diabetes mellitus tipe II (Johnston, 2003), kardiovaskuler (Morton, 2007), kanker , serta menurunkan kadar asam urat (Choi, 2007).…”

Section: Manfaat Kopiunclassified

Pengaruh Pemberian Kopi Terhadap Penurunan Kadar Glukosa Darah Pada Tikus Putih Strain Wistar Diabetes Mellitus Tipe 2

Yustisiani¹,

Andari²,

Isbandiyah³

2017

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ABSTRAKPenilitian ini bertujuan untuk membuktikan pengaruh kopi terhadap penurunan kadar glukosa darah pada tikus putih strain wistar diabetes mellitus tipe 2.penelitin ini menggunakan metode eksperimen laboratoris rancangan the post test only control group desain. Sampel tikus putih strain wistar dibagi 4 kelompok. Sampel I : kontrol negatif, II: kontrol positif, dua kelompok lainnya diberikan kopi Robusta berbagai dosis (5,4 mL/200 gr BB/ hari, 10,8 mL/200 gr BB/hari). Analisis data menggunakan One Way Anova, uji Tukey 5%, uji korelasi dan uji regresi linier. Hasil uji One Way Anova terdapat pengaruh perlakuan dengan perbedaan yang bermakna terhadap penurunan kadar glukosa darah. Dari uji korelasi terdapat korelasi yang berbanding lurus dan sangat bermakna antara dosis kopi dan jumlah penurunan kadar glukosa darah tikus putih diabetes mellitus tipe 2 dengan nilai Pearson Correlation -0,978 pada glukosa darah puasa dan -0,932 pada glukosa darah 2 jam post pandrial, sedangkan hasil uji regresi didapatkan nilai R2 = 0,956 pada glukosa darah puasa dan 0,869 pada glukosa darah 2 jam post pandrial. Kesimpulan : Pemberian kopi berbagai dosis dapat menurunkan kadar glukosa darah tikus diabetes mellitus tipe 2. Kata kunci : diabetes mellitus tipe 2, kadar glukosa darah, kopi Robusta ABSTRACT The objectives of this research were to understanding the effect of coffee to decrease the blood glucose level in diabetes mellitus

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Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine

Cited by 524 publications

References 26 publications

Anticancer Properties of Hydroxycinnamic Acids -A Review

Anticancer Properties of Hydroxycinnamic Acids -A Review

Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey

Pengaruh Pemberian Kopi Terhadap Penurunan Kadar Glukosa Darah Pada Tikus Putih Strain Wistar Diabetes Mellitus Tipe 2

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