Coffee, broccoli and spices are strong inducers of electrophile response element‐dependent transcription in vitro and in vivo – Studies in electrophile response element transgenic mice

Abstract

These results show that plant-based foods contain compounds that can be absorbed and induce the antioxidant defence in a living organism in an organ-specific manner.

The complexity of the Nrf2 pathway: beyond the antioxidant response

“…In general, these naturally occurring compounds can stimulate various upstream kinases, interfere the Keap1-Nrf2 interaction, and/or disturb cellular redox balance, resulting in the activation of the Nrf2 pathway. Administration of these compounds, i.e., sulforaphane [105], curcumin [106, 107], daillyl trisulfide (DATS) [24], epigallocatechin-3-gallate(EGCG) [108, 109] and genistein [31], have been reported to be protective against carcinogenesis, neurodegeneration, cardiovascular disease and diabetic neuropathy in rodent models in part through activation of the Nrf2 pathway. Consuming sufficient amount of fruits and vegetables is not only to meet the nutritional needs but also to boost defense capacity against many oxidative stress and inflammation-associated disease.…”

“…In a long term in vivo study, curcumin showed cancer prevention effect by inducing phase-II antioxidant enzymes via activation of Nrf2 signalling, restoration of tumour suppressor p53 and modulation of inflammatory mediators[106]. After intraperitoneal injection of curcumin to mice, it highly induced Nrf2/ARE activity in intestine, liver, kidney and spleen [107]. Curcumin was found to induce HO-1 expression via activation of Nrf2 by binding to cysteine residue of Keap1 [22].…”

Respiratory Syncytial Virus Infection: Mechanisms of Redox Control and Novel Therapeutic Opportunities

“…EGCG, as well as other catechins contained in green tea, has been shown to modulate Nrf2-dependent gene expression [reviewed in (227)]. Carnasol, a catechol-type antioxidant from Rosmarinus officinalis, increases levels of Nrf2 and the target gene HO-1 in cells, and transgenic mice expressing an ARE-driven luciferase reporter gene, treated by oral gavage with this compound, showed robust ARE activation in different organs (15). Quercetin is capable of activating Nrf2-dependent phase II enzymes (NQO1) in cell lines by both inhibiting ubiquitination of Nrf2 and increasing Nrf2 mRNA [reviewed in (67)].…”

Hormetics: Dietary Triggers of an Adaptive Stress Response

“…One elegant approach was described recently when different spices and herbs, including coffee, were investigated for their ability to activate a luciferase-based reporter gene construct for ARE (66). Finally, simple biomarkers will be needed to estimate the potency of a hormetic stress response in human trials.…”