Coffee consumption and risk of cancers: a meta-analysis of cohort studies

Yu, Xiaofeng; Bao, Zhijun; Zou, Jian; Dong, Jie

doi:10.1186/1471-2407-11-96

Cited by 202 publications

(155 citation statements)

References 82 publications

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“…Despite case-control and cohort studies having reported inconclusive results about the relationship between coffee intake and CHD (10) , it is plausible that the inverse association between light to moderate coffee consumption and all-cause mortality may be partially attributed to the protection against certain kinds of cardiovascular and cerebrovascular diseases. The associations of moderate coffee consumption with the incidence and mortality of cancer varied by body sites and low to moderate coffee consumption was inversely related to total cancer incidence (38) . Whether there is a reverse causality between light to moderate coffee drinking and reduced all-cause mortality requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis

Zhao

Zheng

et al. 2014

Public Health Nutr.

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Objective: We aimed to use the meta-analysis method to assess the relationship between coffee drinking and all-cause mortality. Design: Categorical and dose-response meta-analyses were conducted using random-effects models. Setting: We systematically searched and identified eligible literature in the PubMed and Scopus databases. Subjects: Seventeen studies including 1 054 571 participants and 131 212 death events from all causes were included in the present study. Results: Seventeen studies were included and evaluated in the meta-analysis. A U-shaped dose-response relationship was found between coffee consumption and all-cause mortality (P for non-linearity < 0·001). Compared with non/occasional coffee drinkers, the relative risks for all-cause mortality were 0·89 (95 % CI 0·85, 0·93) for 1-< 3 cups/d, 0·87 (95 % CI 0·83, 0·91) for 3-< 5 cups/d and 0·90 (95 % CI 0·87, 0·94) for ≥5 cups/d, and the relationship was more marked in females than in males. Conclusions:The present meta-analysis of prospective cohort studies indicated that light to moderate coffee intake is associated with a reduced risk of death from all causes, particularly in women.Keywords Meta-analysis Coffee All-cause mortality Prospective cohort study Coffee is one of the most popular beverages in the world and the health-related effects of coffee have been frequently studied. Habitual coffee drinking was reported to be inversely related to the risks of type 2 diabetes(1) and chronic liver disease (2) . As a major dietary source of antioxidants, coffee may also help to improve the resistance of LDL to oxidation and reduce oxidative DNA damage (3) . Results from prospective cohort studies regarding the association of habitual coffee drinking with all-cause mortality were inconclusive (4)(5)(6) . O'Keefe et al. (7) recommended that moderate intake of coffee, tending towards two or three to as many as four cups daily, would be a better choice for keeping healthy rather than excessive coffee consumption. Besides, the association of coffee intake with all-cause mortality may differ between men and women. Lopez-Garcia et al. (8) observed that the significant inverse association of coffee drinking with total mortality was attenuated in men when compared with that in women. Similar results were also found in another large cohort study (9) . A recent meta-analysis of prospective cohort studies suggested that moderate coffee intake was associated with a lower risk of CHD in female drinkers but not in men (10) . However, the health-related effects of coffee may not always be in favour of women. Ascherio et al. (11) reported that coffee consumption was associated with reduced mortality from Parkinson's disease in men but not in women due to the interaction between caffeine and use of postmenopausal oestrogens. Therefore, we conducted a meta-analysis of prospective cohort studies to investigate the association of coffee consumption with all-cause mortality and further to elucidate whether this association varied between male and female coffee drinkers.

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Section: Discussionmentioning

confidence: 99%

Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis

Zhao

Zheng

et al. 2014

Public Health Nutr.

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“…Multiple epidemiological studies have demonstrated an inverse association between coffee consumption and risk of colorectal cancer (4)(5)(6). However, the molecular basis of this effect remains to be fully understood (7).…”

Section: Introductionmentioning

confidence: 99%

Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs

2017

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Abstract.Previous epidemiological studies have demonstrated that moderate coffee consumption is associated with a lower risk of certain types of cancer, particularly colon cancer. To elucidate the molecular basis for this protective action, the effect of coffee on Caco-2 human colon carcinoma cells was investigated. Low concentrations of coffee (<5%) inhibited proliferation of Caco-2 cells without affecting cell viability. Coffee also reduced KRAS proto-oncogene, GTPase (KRAS) gene expression in a dose-dependent manner; however, caffeine, caffeic acid and chlorogenic acid, three major constituents of coffee, did not exhibit this effect. Increasing the duration of coffee bean roasting increased the reduction in KRAS expression, suggesting that the active constituents responsible for this effect emerged during the roasting process. MicroRNA (miR) analysis revealed that coffee induced the expression of miR-30c and miR-96, both of which target the KRAS gene. The results of the present study suggested that daily coffee consumption may reduce KRAS activity, thereby preventing the malignant growth of colon carcinoma cells.

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“…It has been demonstrated that daily drinking of 4-6 cups of regular black coffee, meaning up to 750 mL, is sufficient to prevent carcinogenesis and slow the progression of different types of cancer [33]. The current body of evidence recommends coffee consumption to be included into a healthy lifestyle [30].…”

Section: Chemoprevention In Lung Cancermentioning

confidence: 99%

Diet in lung cancer: back to natural and healthy food

Ciobanu¹

2017

Lung Breath J

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Lung cancer is a complex and multifactorial disease involving genetic, environmental and lifestyle factors. Amongst the latter, nutritional factors are of critical importance, including diet, alcohol consumption, body weight and physical activity. Because of being the most common cancer worldwide in both men and women, preventive measures should be strongly emphasized. The most important risk factor in lung cancer etiology is cigarette smoking, thus preventing the smoking onset and smoking cessation strategies are crucial. Moreover, there are ten nutritional factors to be addressed, like in any other cancer site prevention: alcoholic beverages, overweight and obesity, physical activity, red and processed meat, salt and salted foods, fruits and vegetables, dietary fibers, dairy products, beta-carotene supplements and breastfeeding. People should be more health-conscious, as lean as possible within the normal range of body weight, daily physically active, limit consumption of energy-dense food, of red meat, especially processed meat, salt, and eat mostly foods of plant origin. Avoiding sugary drinks and limiting alcohol intake is strongly advisable. Cancer survivors should follow recommendations for cancer prevention. As proven already, about one third of lung cancer cases are preventable through a healthy, balanced and diversified diet, maintaining a normal weight and practicing regular physical activity.

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Coffee consumption and risk of cancers: a meta-analysis of cohort studies

Cited by 202 publications

References 82 publications

Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis

Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis

Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs

Diet in lung cancer: back to natural and healthy food

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