Coffee consumption and risk of gastric cancer: An updated meta-analysis

Shen, Zhiyong; Liu, Hua; Cao, Hui

doi:10.1016/j.clinre.2014.09.005

Cited by 20 publications

(17 citation statements)

References 20 publications

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“…The inverse correlation between coffee ingestion and deaths from all causes was already described in a large, prospective cohort study in the USA [ 14 ], and in the UK, Tran and collaborators found evidence that suggested an inverse association between coffee consumption and hepatocellular carcinoma [ 15 ]. However, a review of the available evidence collected on coffee drinking and stomach cancer showed heterogeneous and inconclusive results [ 10 , 11 , 13 ]. Shen et al [ 11 ] performed a meta-analysis to evaluate the effect of coffee consumption on the risk of gastric cancer, and found an association ( Relative Risk = 1.24, 95% CI: 1.03–1.49).…”

Section: Discussionmentioning

confidence: 99%

Coffee Consumption and Its Inverse Relationship with Gastric Cancer: An Ecological Study

et al. 2020

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Coffee is the second most popular drink worldwide, and it has various components with antioxidant and antitumor properties. Due to its chemical composition, it could act as an antitumor substance in the gastrointestinal tract. The objective of this study was to explore the relationship between coffee consumption and the incidence/mortality of stomach cancer in the highest-consuming countries. An ecological study using Spearman's correlation coefficient was performed. The WorldAtlas's dataset of coffee consumption and the incidence/mortality rates database of the International Agency for Research were used as sources of information. A total of 25 countries were entered to the study. There was an inverse linear correlation between coffee consumption in kg per person per year and estimated age-adjusted incidence (r = 0.5984, p = 0.0016) and mortality (r = 0.5877, p = 0.0020) of stomach cancer. Coffee may potentially have beneficial effects on the incidence and mortality of stomach cancer, as supported by the data from each country analyzed.

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Section: Discussionmentioning

confidence: 99%

Coffee Consumption and Its Inverse Relationship with Gastric Cancer: An Ecological Study

et al. 2020

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“…Epidemiological studies have reported that coffee may have preventative effects against cardiovascular disease and cancer caused mortality [ 24 ], type 2 diabetes [ 25 ], stroke [ 26 ], prostate cancer [ 27 ] and endometrial cancer [ 28 ]. In contrast, higher coffee intake was found to be associated with increased risk for lung cancer [ 29 ], bladder cancer [ 30 ] and gastric cancer [ 31 ]. Compounds in coffee have been reported to have anticancer activities against UV-light induced skin carcinogenesis in experimental tests [ 32 – 34 ].…”

Section: Discussionmentioning

confidence: 99%

Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

et al. 2016

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BackgroundSeveral epidemiological studies have determined the associations between coffee intake level and skin cancer risk; however, the results were not yet conclusive. Herein, we conducted a systematic review and meta-analysis of the cohort and case-control studies for the association between coffee intake level and malignant melanoma (MM) risk.MethodsStudies were identified through searching the PubMed and MEDLINE databases (to November, 2015). Study-specific risk estimates were pooled under the random-effects model.ResultsTwo case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases) were identified. For caffeinated coffee, the pooled relative risk (RR) of MM was 0.81 [95% confidential interval (95% CI) = 0.68–0.97; P-value for Q-test = 0.003; I2 = 63.5%] for those with highest versus lowest quantity of intake. In the dose-response analysis, the RR of MM was 0.955 (95% CI = 0.912–0.999) for per 1 cup/day increment of caffeinated coffee consumption and linearity dose-response association was found (P-value for nonlinearity = 0.326). Strikingly, no significant association was found between the decaffeinated coffee intake level and MM risk (pooled RR = 0.92, 95% CI = 0.81–1.05; P-value for Q-test = 0.967; I2 = 0%; highest versus lowest quantity of intake).ConclusionsThis meta-analysis suggested that caffeinated coffee might have chemo-preventive effects against MM but not decaffeinated coffee. However, larger prospective studies and the intervention studies are warranted to confirm these findings.

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“…In contrast, metaanalyses conducted for colorectal, colon and rectal cancers (33-35, 50, 65, 141); breast cancer (52,69,119,141); and pancreatic cancer (31,96,104,123,141) showed differences in the statistical significance of the effects, but not in the direction. Moreover, increments in statistical significance or changes in the direction of the association were found in meta-analyses of oral or laryngeal cancer (16,98,124), atrial fibrillation (caffeine exposure) (14,21), gastric cancer (3,27,67,76,112,135,136,143), bladder cancer (43,134,141,154), and Alzheimer's disease and cognitive disorders (caffeine exposure) (58, 79, 109) (Supplemental Table 1).…”

Section: Figurementioning

confidence: 99%

Coffee, Caffeine, and Health Outcomes: An Umbrella Review

2017

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To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet.

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Coffee consumption and risk of gastric cancer: An updated meta-analysis

Cited by 20 publications

References 20 publications

Coffee Consumption and Its Inverse Relationship with Gastric Cancer: An Ecological Study

Coffee Consumption and Its Inverse Relationship with Gastric Cancer: An Ecological Study

Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

Coffee, Caffeine, and Health Outcomes: An Umbrella Review

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