Coffee consumption and the risk of colorectal cancer by anatomical subsite in Japan: Results from the HERPACC studies

Abstract

Consumption of coffee, a popular beverage worldwide, has been associated with lower colorectal cancer (CRC) risk. Although CRC exhibits different biological characteristics by anatomical subsite, the possibly heterogeneous impact of coffee on CRC by anatomical subsite has remained unclear. Here, we conducted two case-control studies to examine the association between coffee consumption and CRC risk as well as risk by anatomic subsite among Japanese using data from the Hospital-based Epidemiological Research Program at Aichi Cancer Center I and II (HERPACC-I and II). Subjects were enrolled in HERPACC-I between 1988 and 2000 and in HERPACC-II between 2001 and 2005. Coffee consumption was measured with a self-administered questionnaire. A conditional logistic regression model was used to calculate odds ratios (ORs) of CRC with coffee consumption, adjusted for potential confounders of age, smoking, alcohol drinking, red meat intake, BMI, exercise, family history of CRC, and diabetes mellitus history. We estimated summary ORs by pooling study-specific ORs with a fixed effects model. In total, 2,696 CRC cases and 13,480 non-cancer outpatients as controls were included. Overall, compared to non-drinkers, ORs of less than 1 cup/day, 1-2 cups/day and 3 or more cups/day for CRC were 0.88 (95% CI: 0.77-1.00), 0.90 (95% CI: 0.80-1.01) and 0.78 (95% CI: 0.65-0.92), respectively (trend-p = 0.009). Subsite-specific analysis revealed a significant inverse linear trend between coffee consumption and distal colon cancer (p-trend = 0.048), and a tendency toward a lower risk of rectal cancer (p-trend = 0.068). These findings suggest that coffee consumption might impact the prevention of CRC, especially distal colon cancer.

Arsenic in HPV Related Oral Carcinoma- A New Threat of the Decade

“…Beverages like tea (green, black) and coffee have also proven to be protective against the occurrence of carcinoma. A study from Japan has also been consistent with this finding, stating the role of coffee in reducing the risk of colon and rectal carcinoma (Senda Nakagawa et al 2017). This is consistent with another study where coffee and tea intake has proven beneficial in case of oral and pharyngeal carcinoma (Garavello et al 2009), while hot maté drinking has been related to increased risk in studies from Argentina and Brazil.…”

Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan

“…However, studies suggest that the ethanol (but not the other components of alcoholic beverages) matters primarily for cancer risk, regardless of the types of alcoholic beverages . In addition, we could not assess other explanatory variables such as menopausal hormone therapy (for female breast cancer), a family history of cancer, diet (eg, coffee and red meat), physical activities, and ALDH2 genotypes . In the JPHC study, alcohol‐related bladder cancer risk was observed in male “flushers” (who are supposed to have polymorphisms in ALDH2 enzyme) but not in male nonflushers .…”

“…9 In addition, we could not assess other explanatory variables such as menopausal hormone therapy (for female breast cancer), a family history of cancer, diet (eg, coffee and red meat), physical activities, and ALDH2 genotypes. 9,14,33 In the JPHC study, alcoholrelated bladder cancer risk was observed in male "flushers" (who are supposed to have polymorphisms in ALDH2 enzyme) but not in male nonflushers. 9 In the assessment of how robust our estimate (OR for ever drinkers, 1.18) was to potential unmeasured and uncontrolled confounding, the E-value was 1.64.…”

Reevaluation of a rightward shift in colorectal cancer: A single‐center retrospective study in Tianjin

“…49,50 In contrast, coffee consumption is inversely proportional to the risk of LSCRC. 51 Cigarette smoking and diabetes mellitus are associated with an increased risk of RSCC. [52][53][54] There were some limitations to our study.…”