Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study

Gelder, B.M. van; Buijsse, Brian; Tijhuis, Marja; Kalmijn, Sandra; Giampaoli, Simona; Nissinen, Aulikki; Kromhout, Daan

doi:10.1038/sj.ejcn.1602495

Cited by 209 publications

(169 citation statements)

References 26 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…The authors reported an inverse J-shaped curve between the number of cups of coffee consumed and the extent of cognitive decline, with the least cognitive decline for 3 cups coffee daily (2%). This decline was 4.3 times significantly smaller than in non-consumers [92]. Finally, the most recent cohort study included 923 healthy adults from Scotland belonging to the Lothian Birth Control 1936 Study, in which the IQ of the children was assessed at 11 years.…”

Section: A Nehlig / Is Caffeine a Cognitive Enhancer?mentioning

confidence: 99%

Is Caffeine a Cognitive Enhancer?

Nehlig

2010

JAD

313

252

View full text Add to dashboard Cite

Abstract. The effects of caffeine on cognition were reviewed based on the large body of literature available on the topic. Caffeine does not usually affect performance in learning and memory tasks, although caffeine may occasionally have facilitatory or inhibitory effects on memory and learning. Caffeine facilitates learning in tasks in which information is presented passively; in tasks in which material is learned intentionally, caffeine has no effect. Caffeine facilitates performance in tasks involving working memory to a limited extent, but hinders performance in tasks that heavily depend on working memory, and caffeine appears to rather improve memory performance under suboptimal alertness conditions. Most studies, however, found improvements in reaction time. The ingestion of caffeine does not seem to affect long-term memory. At low doses, caffeine improves hedonic tone and reduces anxiety, while at high doses, there is an increase in tense arousal, including anxiety, nervousness, jitteriness. The larger improvement of performance in fatigued subjects confirms that caffeine is a mild stimulant. Caffeine has also been reported to prevent cognitive decline in healthy subjects but the results of the studies are heterogeneous, some finding no age-related effect while others reported effects only in one sex and mainly in the oldest population. In conclusion, it appears that caffeine cannot be considered a 'pure' cognitive enhancer. The indirect action of caffeine on arousal, mood and concentration contributes in large part to its cognitive enhancing properties.

show abstract

Section: A Nehlig / Is Caffeine a Cognitive Enhancer?mentioning

confidence: 99%

Is Caffeine a Cognitive Enhancer?

Nehlig

2010

JAD

313

252

View full text Add to dashboard Cite

show abstract

“…One suggestion for these results is that caffeine ingestion may reverse the effects of cognitive aging by making greater energy reserves available in older adults (13,14) with some evidence demonstrating that such effects of caffeine ingestion may be more marked in older adults compared to younger adults (11).…”

Section: Introductionmentioning

confidence: 99%

The effect of caffeine ingestion on functional performance in older adults

Duncan

Clarke

Tallis

et al. 2014

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Caffeine is a widely used nutritional supplement which has been shown to enhance both physical and cognitive performance in younger adults.However, few studies have assessed the effect of caffeine ingestion on performance, particularly functional performance in older adults. The present study aims to assess the effect of acute caffeine ingestion on functional performance, manual dexterity and readiness to invest effort in older adults.Methods: 19 apparently healthy, volunteers (10 females and 9 males aged 61-79; 66±2 years) performed tests of functional fitness and manual dexterity post ingestion of caffeine (3mg*kg -1 ) or placebo in a randomised order. Pre and 60 minutes post ingestion, participants also completed measures of readiness to invest physical (RTIPE) and mental (RTIME) effort. Results: A series of repeated measures ANOVAS indicated enhanced performance in the following functional fitness tests; arm curls (P = .04), 8 foot up and go (P = .007), six minute walk (P = .016). Manual dexterity was also improved in the presence of caffeine (P = .001). RTIME increased (P = .015) pre to post ingestion in the caffeine condition but not in the placebo condition. There were no significant main effects or interactions for RTIPE or gender in any analysis (all P>.05). Conclusions: The results of this study suggest that acute caffeine ingestion positively enhances functional performance, manual dexterity and readiness to invest effort in apparently healthy older adults.

show abstract

“…Eskelinen et al (2009) reported a 65 % risk reduction for late-life dementia and AD among drinkers of three to five cups of coffee per day during their middle life, compared with nondrinkers. The caffeine in coffee has been implicated as the active component associated with risk reduction of cognitive decline and dementia among coffee drinkers (Maia and de Mendonca 2002;van Gelder et al 2007), particularly among women (Ritchie et al 2007;Santos et al 2010). However, coffee also contains a variety of other bioavailable and potentially therapeutic phytochemicals.…”

Section: Introductionmentioning

confidence: 99%

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Shukitt‐Hale

Miller

Chu

et al. 2013

AGE

View full text Add to dashboard Cite

The complex mixture of phytochemicals in fruits and vegetables provides protective health benefits, mainly through additive and/or synergistic effects. The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging. Moderate (three to five cups a day) coffee consumption in humans is associated with a significant decrease in the risk of developing certain chronic diseases. However, the ability of coffee supplementation to improve cognitive function in aged individuals and the effect of the individual components in coffee, such as caffeine, have not been fully evaluated. We fed aged rats (19 months) one of five coffeesupplemented diets (0, 0.165, 0.275, 0.55, and 0.825 % of the diet) for 8 weeks prior to motor and cognitive behavior assessment. Aged rats supplemented with a 0.55 % coffee diet, equivalent to ten cups of coffee, performed better in psychomotor testing (rotarod) and in a working memory task (Morris water maze) compared to aged rats fed a control diet. A diet with 0.55 % coffee appeared to be optimal. The 0.165 % coffeesupplemented group (three cups) showed some improvement in reference memory performance in the Morris water maze. In a subsequent study, the effects of caffeine alone did not account for the performance improvements, showing that the neuroprotective benefits of coffee are not due to caffeine alone, but rather to other bioactive compounds in coffee. Therefore, coffee, in achievable amounts, may reduce both motor and cognitive deficits in aging.

show abstract

Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study

Cited by 209 publications

References 26 publications

Is Caffeine a Cognitive Enhancer?

Is Caffeine a Cognitive Enhancer?

The effect of caffeine ingestion on functional performance in older adults

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Contact Info

Product

Resources

About