Coffee: Good, Bad, or Just Fun? A Critical Review of Coffee's Effects on Liver Enzymes

Homan, David; Mobarhan, Sohrab

doi:10.1301/nr.2006.jan.43-46

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…Earlier meta‐analyses have reported an inverse association between coffee consumption and liver cancer . Studies have also reported protective effects of coffee in animals with liver disease and in humans where the outcomes were less severe CLD including abnormal LFTs . However, this is the first meta‐analysis to show a protective effect of coffee against cirrhosis.…”

Section: Discussionmentioning

confidence: 71%

“…10,30,31 Studies have also reported protective effects of coffee in animals with liver disease and in humans where the outcomes were less severe CLD including abnormal LFTs. 9,32,33 However, this is the first meta-analysis to show a protective effect of coffee against cirrhosis. The analysis of five cohort and four case-control studies has shown that increasing daily coffee consumption by two cups is associated with a near halving of the risk of cirrhosis.…”

Section: Discussionmentioning

confidence: 85%

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Systematic review with meta‐analysis: coffee consumption and the risk of cirrhosis

Kennedy

Roderick

Buchanan

et al. 2016

Aliment Pharmacol Ther

103

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 85%

Systematic review with meta‐analysis: coffee consumption and the risk of cirrhosis

Kennedy

Roderick

Buchanan

et al. 2016

Aliment Pharmacol Ther

103

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“…Coffee consumption has been associated with lower serum liver enzyme levels and a reduced risk of liver cirrhosis in mice and man (36)(37)(38). Indication of a protective effect has also been seen in the cohort and case-control studies of coffee and hepatocellular carcinoma.…”

Section: Hepatocellular Cancermentioning

confidence: 94%

Epidemiologic Evidence on Coffee and Cancer

Arab

2010

Nutrition and Cancer

107

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Coffee consumption is a major and frequent dietary exposure in diverse cultures around the globe whose safety has been questioned. A substantial body of epidemiologic evidence, consisting of over 500 papers relating the consumption of coffee to cancer of various sites, has accumulated to date. Numerous individual, site-specific meta analyses have been undertaken at various times. However, there is no comprehensive, up-to-date overview of the entirety of the knowledge base. To address this need, this review summarized the findings of the meta analyses and recent papers on site-specific human cancers among coffee consumers. For hepatocellular and endometrial cancers, there appears to be a strong and consistent protective association; for colorectal cancer, the direction of association is borderline protective. There appears to be no association with breast, pancreatic, kidney, ovarian, prostate, or gastric cancer. Risk of bladder cancer appears to be associated with heavy coffee consumption in some populations and among men. The associations with childhood leukemia and mother's consumption of coffee were ambiguous-with some suggestion of risk at high levels of daily consumption.

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“…In an experimental study with rats, researchers found that the consumption of instant coffee had a protective effect against liver injury (Ozercan et al, 2006). Other studies of liver disease have also suggested that the compounds cafestol and kahweol, found primarily in ground and non-filtered coffees, may provide some protection, but even this is unclear and requires more investigation (Homan and Mobarhan, 2006). Until further research is conducted, coffee will not likely be recommended to patients with or at risk for liver or gallstone disease, yet there is also very little evidence that such patients have anything to lose or to risk by drinking coffee in the meantime (Table I).…”

Section: Digestive Systemmentioning

confidence: 99%

To sip or not to sip: the potential health risks and benefits of coffee drinking

Taylor

Adams

2007

Nutrition &Amp; Food Science

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Purpose -The purpose of this review is to provide a comprehensive summary of current research on the health risks and benefits associated with coffee drinking. Design/methodology/approach -This review includes up-to-date information from the original literature on coffee drinking and health and presents findings in a manner accessible to both experts and non-experts. Findings -Coffee contains caffeine, antioxidants, and other phytochemicals, all of which affect disease risks. There is evidence that coffee drinking may not be suitable for certain individuals. Overall, however, coffee drinking seems to be a non-harmful habit for those who drink it regularly and in moderation, and recent studies indeed suggest that it may even be beneficial for most people. The most currently available evidence suggests that coffee drinking can help reduce the risk of several diseases, most notably type 2 diabetes, Alzheimer's disease, and Parkinson's disease, although the underlying mechanisms for this effect are still being investigated. Practical implications -Current studies suggest that coffee drinkers can help protect themselves from neurodegenerative and other diseases by drinking an average of two cups of regular, filtered coffee per day. Originality/value -This article provides accessible and comprehensive information to researchers, nutritionists, and consumers who are interested in the potential health risks and benefits of regular and moderate coffee drinking.

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Coffee: Good, Bad, or Just Fun? A Critical Review of Coffee's Effects on Liver Enzymes

Cited by 4 publications

References 4 publications

Systematic review with meta‐analysis: coffee consumption and the risk of cirrhosis

Systematic review with meta‐analysis: coffee consumption and the risk of cirrhosis

Epidemiologic Evidence on Coffee and Cancer

To sip or not to sip: the potential health risks and benefits of coffee drinking

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