1995
DOI: 10.1093/jn/125.9.2301
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Coffee Oil Consumption Does Not Affect Serum Cholesterol in Rhesus and Cebus Monkeys

Abstract: Oil from coffee beans contains the diterpenes cafestol and kahweol, which greatly elevate cholesterol in humans. Consumption of 0.03 g coffee oil (0.86 mg cafestol and 1.04 mg kahweol)/kg body wt raised serum cholesterol by 1.27 mmol/L in volunteers. We fed coffee oil from this same batch to cebus and rhesus monkeys. Two groups of eight cebus monkeys were fed a purified diet containing 0.5% coffee oil or placebo oil (sunflower plus palm oil, 3:2, wt/wt) for 2 x seven and a half weeks in a crossover design. The… Show more

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Cited by 15 publications
(12 citation statements)
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“…In contrast to the previously described findings in African green monkeys, coffee oil did not affect plasma cholesterol and triacylglycerols in cebus and rhesus monkeys (Terpstra et al 1995). These monkeys consumed a daily amount of cafestol corresponding to that present in twelve to thirteen cups of boiled coffee per 10 MJ diet (Fig.…”
Section: Coffee Diterpenes Fail To Show Consistent Results In Other Acontrasting
confidence: 53%
See 1 more Smart Citation
“…In contrast to the previously described findings in African green monkeys, coffee oil did not affect plasma cholesterol and triacylglycerols in cebus and rhesus monkeys (Terpstra et al 1995). These monkeys consumed a daily amount of cafestol corresponding to that present in twelve to thirteen cups of boiled coffee per 10 MJ diet (Fig.…”
Section: Coffee Diterpenes Fail To Show Consistent Results In Other Acontrasting
confidence: 53%
“…This diet was supplemented with either a placebo oil consisting of sunflower oil and palm oil (3:2, w/w), or with coffee oil. Both oils had a similar content of fatty acids (Terpstra et al 1995). The diets provided 0·26 g coffee oil or placebo oil/kg body weight per d; as a result the coffee-oil diet provided 8 mg cafestol and 7 mg kahweol/kg body weight per d. During a run-in period of 6 weeks, all monkeys consumed the placebo-oil diet.…”
Section: Effect Of Coffee Diterpenes In African Green Monkeys and Hummentioning
confidence: 99%
“…Insight into meta- [28] were also negative, regardless of the dosage, the mode of administration, the duration of treatment and the cholesterol content of the background diet. Cebus and Rhesus monkeys did not respond to the coffee oil that we had used in our human studies ( Figure 3) [29]. It is possible that differences in absorption or metabolism of coffee diterpenes account for this curious species-specificity.…”
Section: Sites Of Action Of Coffee Diterpenesmentioning
confidence: 94%
“…Humans ingested 0 03 g of coffee oil per kg body weight for 4 weeks in a placebo-controlled trial (n = 12-I 6 per group) [3] Cebus monkeys (n = 16) ingested 0 I 8 g per kg body weight of either placebo or coffee oil in a cross-over study of 2 x 7 5 weeks, and Rhesus monkeys (n = 6) 0 20 g per kg body weight of either placebo or coffee oil in a cross-over study of 2 x 6 weeks [29] Could the hyperlipidaemic effects of coffee diterpenes be secondary to their effect on the liver? We found no Consistent effects on Serum bilirubin levels and alkaline phosphatase activities, which appears to exclude cholestasis.…”
Section: Effect Of Coffee Oil Prepared By Hexane Extraction Of Spent mentioning
confidence: 99%
“…5 The availability of an animal model to study this hypothesis in vivo would be of great value, since it may help us to validate our in vitro experiments and eventually to discover the metabolic control points of cafestol. However, in previous studies, various animal models like hamsters 6 -8 ; rats 6,9 ; gerbils 8 ; and Cebus, Rhesus, and African green monkeys 10 did not respond to cafestol and kahweol as humans do, regardless of the dosage, the mode of administration, or the duration of treatment.…”
mentioning
confidence: 89%