Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects

Wang, Qian; Hu, Gui-Lin; Qiu, Ming-Hua; Cao, Jun; Xiong, Wen-Yong

doi:10.1016/j.crfs.2024.100741

Cited by 5 publications

(1 citation statement)

References 183 publications

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“…Coffee, tea, and cocoa-derived bioactive components possessing anti-obesity effects include chlorogenic acid, trigonelline, kahweol, catechins, epigallocatechin gallate, theaflavins, thearubigins, and quercetin [ 173 ].…”

Section: Small Molecule Compounds and Dietary Moleculesmentioning

confidence: 99%

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Boychenko,

Egorova,

Brovin

et al. 2024

Pharmaceuticals

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Obesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the influences of environment and reduced physical activity. Two types of adipose tissue widely known are white and brown. While white adipose tissue functions predominantly as a key energy storage, brown adipose tissue has a greater mass of mitochondria and expresses the uncoupling protein 1 (UCP1) gene, which allows thermogenesis and rapid catabolism. Even though white and brown adipocytes are of different origin, activation of the brown adipocyte differentiation program in white adipose tissue cells forces them to transdifferentiate into “beige” adipocytes, characterized by thermogenesis and intensive lipolysis. Nowadays, researchers in the field of small molecule medicinal chemistry and gene therapy are making efforts to develop new drugs that effectively overcome insulin resistance and counteract obesity. Here, we discuss various aspects of white-to-beige conversion, adipose tissue catabolic re-activation, and non-shivering thermogenesis.

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Section: Small Molecule Compounds and Dietary Moleculesmentioning

confidence: 99%

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Boychenko,

Egorova,

Brovin

et al. 2024

Pharmaceuticals

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Structural characteristics and nonvolatile metabolites of theabrownins and their impact on intestinal microbiota in high-fat-diet-fed mice

Zhang,

Wang,

Wang

et al. 2025

Food Chemistry

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Nutrient molecules affecting the white-to-beige adipose tissue transition

Egorova,

Gurtsieva,

Egorov

2024

Obes. metabol.

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Obesity is one of the most important health problems. Body weight can be controlled through a combination of a healthy diet and physical activity, but hypertrophic obesity is often complicated by other comorbidities such as type 2 diabetes mellitus (T2DM), cardiovascular disease, hypertension and various forms of arthritis. If intense physical activity is contraindicated for patients, then alternative approaches to combat obesity can be developed. The discovery of beige adipocytes in white adipose tissue has attracted attention to their use as a target for therapy. There are molecules of various origin that are capable of modulating the formation of beige adipocytes by interacting with critical signaling cascades, leading to increased thermogenesis. One such approach would be to stimulate the transition of white adipose tissue cells into more catabolically active beige cells using nutrients and small molecule drugs.

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Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects

Cited by 5 publications

References 183 publications

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Structural characteristics and nonvolatile metabolites of theabrownins and their impact on intestinal microbiota in high-fat-diet-fed mice

Nutrient molecules affecting the white-to-beige adipose tissue transition

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