Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

Abstract

Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Results Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction.

Daily Coffee and Green Tea Consumption Is Inversely Associated with Body Mass Index, Body Fat Percentage, and Cardio-Ankle Vascular Index in Middle-Aged Japanese Women: A Cross-Sectional Study

“…In addition, CGA also has anti-atherosclerotic properties [ 21 ]. A single-blind, randomized, placebo-controlled, crossover trial showed that a single intake of CF with a high content of CGA and a low content of hydroxyhydroquinone, which oxidizes CGA and reduces its function, improved postprandial endothelial dysfunction by decreasing oxidative stress [ 22 ]. A recent meta-analysis of randomized clinical trials reported the antihypertensive effect of CGA [ 23 ].…”

Implication of dietary phenolic acids on inflammation in cardiovascular disease

“…Coffee with high chlorogenic acid and low hydroxyhydroquinone content (but not coffee with high chlorogenic acid and hydroxyhydroquinone content or placebo coffee), improved postprandial endothelial function with decreased 8-isoprostane levels in plasma. Kajikawa et al, 2019 Healthy subjects, males (N = 17), aged 24-26 years.…”

Do Coffee Polyphenols Have a Preventive Action on Metabolic Syndrome Associated Endothelial Dysfunctions? An Assessment of the Current Evidence

“…The mechanism of the beneficial effect of chlorogenic acid was associated with the production of NO and induction of heme oxygenase-1 [ 94 ]. Consumption of coffee with a high content of chlorogenic acids repaired endothelial dysfunction by decreasing oxidative stress [ 95 ]. A previous study indicated that oxidative stress has been demonstrated to play a important role in the development of endothelial dysfunction [ 96 ].…”