Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure
Sunghyun Kim,
Sumin Sohn,
Eun Sang Choe
Abstract:Background
Nicotine dependence is associated with changes in glutamatergic neurotransmission in the caudate and putamen (CPu) of the forebrain. Changes in the structure of dendritic spines in the glutamate synapses after nicotine exposure induce habitual behaviors such as smoking. The present study investigated the hypothesis that cofilin, an actin-binding protein that is linked to the GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors regulates the morphology of dendritic spines in the neurons of the C… Show more
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