It is necessary to ensure safety in terms of health and accidents through the real-time monitoring of the construction site environment and workers. This problem has become of great importance due to the economic and social implications. Therefore, a sensor-based approach has been found to be beneficial in Building Information Modeling (BIM). Wireless Sensor Network (WSN) technologies are well-suited for the deployment of monitoring systems. A suitable technical solution for node communication in a WSN is Long Range (LoRa) modulation technology. In this study, an autonomous LoRa-based system for the monitoring of a construction site in Lungro, Calabria, Italy, is presented. The spatial monitoring of working personnel is achieved by employing a tracker device with an Inertial Measurement Unit (IMU) and a Global Positioning System (GPS) device. Accesses of personnel and gear to the site are registered using Radio Frequency Identification (RFID) tags equipped with protective gear. Fixed-position solar-powered sensor nodes are also employed for structural monitoring, i.e., movement sensors are used to monitor the variation of scaffolding, building structures, and under-work housing inclinations. Long Range Wide Area Network (LoRaWAN) gateways interface with the nodes and the internet for data exchange, enabling an Internet of Things (IoT) paradigm for the monitoring solution. A comprehensive overview of the workers and structural nodes, along with the RFID access management system and LoRaWAN gateway features, is provided in this article. A description of the web interface is also reported.