Cognition in Parkinson disease: An event‐related potential perspective

Abstract

Auditory event-related potentials (ERP) elicited in a target detection stimulus paradigm and pattern-shift visual ERPs were studied in 20 male patients with idiopathic Parkinson disease (PD) and 20 age-matched normal controls. Patients showed significantly increased latencies for both the P200 and P300 components of the auditory ERP. Patients and controls showed no significant differences in latency of the visual ERP but patients showed significantly decreased amplitude. Only one of five neuropsychological measures, the Symbol Digit Modalities test (SDMT), showed a significant negative correlation with P300 latency. The significant association between the two measures that showed impairments in the PD patients (P300 latency and SDMT scores) suggested that these measures reflect a common, disrupted aspect of cognitive function in PD.

Updating P300: An integrative theory of P3a and P3b

“…These data suggest that at least the P3a and some portion of the P3b are affected by dopaminergic activity (Polich and Criado, 2006). Several lines of evidence imply catecholaminergic mediation of frontal P300 (P3a) generation: (1) Parkinson disease patients who have decreased levels of dopamine demonstrate deficient P300 measures (Hansch et al, 1982;Stanzione et al, 1991). (2) The dopamine antagonist sulpiride increases P300 in low-amplitude subjects and decreases it in high-amplitude subjects (Takeshita and Ogura, 1994).…”

Cognitive Evoked Potentials (P300) in Early Huntington's Disease

“…Those averaged potentials with coincident eye movement were also accepted for analysis if the scalp distribution of the P3 component was larger at P, than at F ... indicating that the contribution of eye movement-related potentials to the P3 was probably insignificant. If these two 102 (10) 122 (6) 106 ( criteria were not met, the tracings were not included in the results. The mean latencies of components Nl and P2 were compared with the normal values for the two modalities developed in our laboratory from individuals between the ages of 20 and 80 years {C.R., A.S., L. W. Meyer, unpublished data, 1983).…”

Event-Related Potentials in Parkinson’s Disease: A Review

“…Correlations concerning the tests of general intellectual abilities, attention and vi suospatial abilities, as well as language and memory were not substantially different from those found for P3. P2 Hansch et al (1982) observed a significant correlation of P2 wave latency with SDMT scores (r = -0.499, P < 0.05).…”

“…During the last 10 years, since the original report of Hansch et al (1982), several studies have attempted to specify ERP indices of cognitive disturbances occurring in Parkinson's disease.…”