Cognitive Ability and Impairment Related to Formaldehyde

He, Rong

doi:10.1007/978-94-024-1177-5_8

Cited by 3 publications

(3 citation statements)

References 82 publications

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“…An increasing number of studies have elucidated the important role of FA in the pathogenesis of AD ( He, 2017b ). FA, a biomarker of inflammation in oxidative stress, has been associated with a variety of cognitive impairments ( He, 2017a ). Normally, the FA levels in the human body are maintained at 10–80 μmol/L ( Szende and Tyihák, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer’s disease: A systematic review and meta-analysis

Chen

Wang

Tian

et al. 2022

Front. Aging Neurosci.

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BackgroundFormaldehyde (FA), a toxic aldehyde, has been shown to be associated with a variety of cognitive disorders, including Alzheimer’s disease (AD). There is increasing evidence that FA levels are significantly increased in AD patients and may be involved in the pathological process of AD. The aim of this study was to assess the potential diagnostic value of urine FA levels in AD using meta-analysis techniques.MethodsOriginal reports of morning urine FA levels in AD patients and healthy controls (HCs) were included in the meta-analysis. Standardized mean differences (SMD) were calculated using a random-effects model, heterogeneity was explored using methodological, age, sex difference and sensitivity analyses, and receiver operating characteristic (ROC) curves were constructed to assess the diagnostic value of urine FA levels in AD.ResultsA total of 12 studies were included, and the urine FA levels of 874 AD patients and 577 HCs were reviewed. Compared with those in HCs, the FA levels were significantly increased in AD patients. The heterogeneity of the results did not affect their robustness, and results of the area under the curve (AUC) suggested that urine FA levels had good potential diagnostic value.ConclusionUrine FA levels are involved in AD disease progression and are likely to be useful as a potential biomarker for clinical auxiliary diagnosis. However, further studies are needed to validate the results of this study.

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Section: Discussionmentioning

confidence: 99%

The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer’s disease: A systematic review and meta-analysis

Chen

Wang

Tian

et al. 2022

Front. Aging Neurosci.

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“…In recent years, abnormal formaldehyde metabolism has been recognized as one of the essential features of age-related cognitive impairment ( Yu et al, 2014 ; He, 2017 ). Our previous study reported a correlation between urinary formaldehyde levels and cognitive function, suggesting that urinary formaldehyde is a potential biomarker for the early diagnosis of AD ( Wang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Formaldehyde plays a vital role in cellular metabolism and is involved in one-carbon metabolism, providing carbon for synthesizing and modifying biological compounds such as DNA, RNA, and amino acids ( Li et al, 2021 ; Morellato et al, 2021 ). In the brain, formaldehyde can promote spatial memory formation under physiological conditions, and high formaldehyde concentrations can lead to protein denaturation and impair memory function ( Tulpule and Dringen, 2013 ; He, 2017 ; Kou et al, 2022 ). Some studies have reported that formaldehyde concentrations were higher in the brains of patients with AD ( He et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer’s disease

Wang

Zhu³

et al. 2022

Front. Aging Neurosci.

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IntroductionThe accumulation of endogenous formaldehyde is considered a pathogenic factor in Alzheimer’s disease (AD). The purpose of this study was to investigate the relationship between urinary formic acid and plasma biomarkers in AD.Materials and methodsFive hundred and seventy-four participants were divided into five groups according to their diagnosis: 71 with normal cognitive (NC), 101 with subjective cognitive decline (SCD), 131 with cognitive impairment without mild cognitive impairment (CINM), 158 with mild cognitive impairment (MCI), and 113 with AD.ResultsWith the progression of the disease, urinary formic acid levels showed an overall upward trend. Urinary formic acid was significantly correlated with Mini-Mental State Examination (MMSE) scores, the Chinese version of Addenbrooke’s Cognitive Examination III (ACE-III) scores, and Montreal Cognitive Assessment-Basic (MoCA-B) time. The areas under the receiver operating characteristic curves (AUC) of urinary formic acid in distinguishing NC from AD was 0.797, which was similar to that of plasma neurofilament light chain (NfL; AUC = 0.768) and better than other plasma biomarkers (Aβ40, Aβ42, Aβ42/Aβ40, T-tau, P-tau181, and P-tau181/T-tau). We also found that using urinary formic acid and formaldehyde levels could improve the accuracy of using plasma biomarkers to determine AD disease stage.DiscussionOur study revealed the possibility of urinary formic acid as a potential novel biomarker for the early diagnosis of AD.

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Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

Li¹,

Wei

et al. 2021

Genes

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Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets.

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Cognitive Ability and Impairment Related to Formaldehyde

Cited by 3 publications

References 82 publications

The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer’s disease: A systematic review and meta-analysis

The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer’s disease: A systematic review and meta-analysis

Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer’s disease

Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

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