Cognitive abnormalities in multiple sclerosis: a psychometric and MRI study

Ron, María A.; Callanan, Margie; Warrington, E. K.

doi:10.1017/s0033291700014653

Cited by 110 publications

(56 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have already found that duration of the disease and physical disability are not strictly linked with the cognitive functioning of these patients [6][7][8][9][10]20]. This lack of correlation is partly not surprising, since EDSS reflects mainly cerebellar, brainstem and spinal cord involvement.…”

Section: Resultsmentioning

confidence: 87%

Influence of Clinical Variables on Neuropsychological Performance in Multiple Sclerosis

et al. 1994

View full text Add to dashboard Cite

The effects of age, educational level, duration and course of the disease, physical disability and mood status on several cognitive functions (short- and long-term memory, frontal functions, attention, language and visuospatial skills) have been evaluated in 42 multiple sclerosis (MS) patients. The Hamilton Depression Rating Scale (HDRS) scores and a secondary progressive disease course significantly influenced neuropsychological performance. Factorial analysis revealed that indexes of (1) frontal function impairment, (2) long-term verbal memory and language function impairment, and (3) visuospatial short- and long-term memory and visuoperceptive function impairment accounted for 85% of the variance in neuropsychological performance. Only the first factor was significantly related to the presence of depressive symptomatology, as assessed by the HDRS. These results indicate that both the course of the disease and the presence of affective disorders must be taken into account when evaluating the natural history of cognitive impairment in MS and suggest that depressive symptomatology and cognitive dysfunction in MS are related to the involvement of at least partially overlapping anatomofunctional circuits.

show abstract

Section: Resultsmentioning

confidence: 87%

Influence of Clinical Variables on Neuropsychological Performance in Multiple Sclerosis

et al. 1994

View full text Add to dashboard Cite

show abstract

“…Although psychopathological symptoms in multiple sclerosis have been known since the early descriptions of the disease and mental functions in MS were investigated in some detail already almost 90 years ago (e. g. [51]), essential contributions to the understanding of cognitive deficits were made in the last five decades (e. g., [12,50] ■ Abstract Neuropsychological dysfunctions have been well documented in patients with multiple sclerosis. We herein give an overview of the main findings of recent decades.…”

Section: Neuropsychology Of Multiple Sclerosismentioning

confidence: 99%

Neuropsychology of multiple sclerosis

Calabrese

2006

J Neurol

121

View full text Add to dashboard Cite

Neuropsychological dysfunctions have been well documented in patients with multiple sclerosis. We herein give an overview of the main findings of recent decades. The pros and cons of considering the cognitive deficits of multiple sclerosis patients as a form of 'subcortical dementia' are discussed. By comparing the neuropsychological descriptions of multiple sclerosis patients as given in the literature to other neurological diseases which are also associated with neuropsychological deficiencies, we propose the term 'multiple disconnection syndrome' to describe the variety of neuropsychological deficits encountered in this demyelinating disease. Furthermore, a ' threshold of cerebral tolerance' is assumed which must be crossed before cognitive dysfunctions are manifested clinically.

show abstract

“…The cognitive domains most commonly impaired are memory, attention, information processing, executive function, and visuospatial abilities (Rao et al, 1991a;Ron et al, 1991). The pathophysiology of neuropsychological (NP) deficits is, at least partially, unclear.…”

Section: Introductionmentioning

confidence: 99%

Perfusion Magnetic Resonance Imaging Correlates of Neuropsychological Impairment in Multiple Sclerosis

Inglese

Adhya

Johnson

et al. 2007

J Cereb Blood Flow Metab

106

View full text Add to dashboard Cite

Although cognitive impairment is common in multiple sclerosis (MS), its pathophysiology is still poorly understood. Abnormalities of cerebral blood flow (CBF) have long been acknowledged in MS and advances in perfusion magnetic resonance imaging (MRI) allow for their assessment in vivo. We investigated the relationship between regional perfusion changes and neuropsychological (NP) dysfunctions in patients with relapsing-remitting and primary-progressive MS. Absolute CBF, cerebral blood volume (CBV) and mean transit time were measured in 32 MS patients and 11 healthy controls using dynamic susceptibility contrast-enhanced T2*-weighted MRI. A comprehensive NP test battery was administered to all patients. A mixed model analysis of covariance was performed for group comparisons in terms of perfusion measures in normal-appearing white matter (NAWM) and deep gray matter (GM). Pearson's correlations were used to describe the association of perfusion metrics with NP Z-scores. CBF and CBV values were significantly decreased in both NAWM and deep GM in MS patients compared with controls (P = 0.01). In all patients, deep GM CBF was significantly associated with Rey Complex Figure Test (RCFT)-Copy (r = 0.5; P = 0.001) and deep GM CBV and NAWM CBV were significantly associated with Color-Word Interference Inhibition Switching test (D-KEFSIS) (r = 0.4; P = 0.008 and r = 0.4; P = 0.02). However, the only associations that remained significant after Bonferroni correction were between deep GM CBF and RCFT-Copy (P = 0.006), and deep GM CBV and D-KEFSIS (P = 0.04). Our results suggest a role for tissue perfusion impairment in NP dysfunction in MS. Large-scale studies are needed to characterize better this association.

show abstract

Cognitive abnormalities in multiple sclerosis: a psychometric and MRI study

Cited by 110 publications

References 37 publications

Influence of Clinical Variables on Neuropsychological Performance in Multiple Sclerosis

Influence of Clinical Variables on Neuropsychological Performance in Multiple Sclerosis

Neuropsychology of multiple sclerosis

Perfusion Magnetic Resonance Imaging Correlates of Neuropsychological Impairment in Multiple Sclerosis

Contact Info

Product

Resources

About