Cognitive activities and cognitive performance in middle-aged adults at risk for Alzheimer’s disease.

Jonaitis, Erin M.; Rue, Asenath La; Mueller, Kimberly D.; Koscik, Rebecca L.; Hermann, Bruce P.; Sager, Mark A.

doi:10.1037/a0034838

Cited by 55 publications

(59 citation statements)

References 66 publications

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“…As for socio-demographic factors, corroborating other studies 6,20,32,40,47,48,49 , we found that more schooling significantly reduced the odds of cognitive decline.…”

Section: Discussionsupporting

confidence: 81%

Atividades avançadas de vida diária e incidência de declínio cognitivo em idosos: Estudo SABE

et al. 2015

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O objetivo deste trabalho foi avaliar o impacto das atividades avançadas de vida diária (AAVD) na incidência de declínio cognitivo. A amostra foi composta por idosos participantes do estudo longitudinal Saúde, Bem-estar e Envelhecimento (SABE). O declínio cognitivo foi avaliado por meio do Mini - Exame do Estado Mental abreviado. As AAVD compreenderam 12 atividades sociais, produtivas, físicas e de lazer que envolvem funções cognitivas superiores. Foram considerados grupos de covariáveis do estudo: fatores sociodemográficos, saúde geral, estilo de vida e funcionalidade. A associação entre a incidência de declínio cognitivo e as variáveis independentes foi avaliada usando-se o modelo de regressão de Poisson múltiplo. A incidência de declínio foi de 7,9%. A média de desempenho de AAVD em 2006 foi significativamente maior entre os idosos que não desenvolveram o declínio. Após análise multivariada os resultados mostraram que quanto maior o número de AAVD realizadas menor a chance de declínio cognitivo no período estudado.

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“…As for socio-demographic factors, corroborating other studies 6,20,32,40,47,48,49 , we found that more schooling significantly reduced the odds of cognitive decline.…”

Section: Discussionsupporting

confidence: 81%

Atividades avançadas de vida diária e incidência de declínio cognitivo em idosos: Estudo SABE

et al. 2015

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“…This included people at increased risk for AD due to parental family history (76.16% FH+) in both the Wisconsin Registry for Alzheimer’s Prevention (WRAP; n=127, 84.1%) and the Wisconsin Alzheimer’s Disease Research Center (WADRC; n=24, 15.9%) if they had undergone at least two DTI scans and at least one lumbar puncture. These cohorts have been described previously (Sager et al 2005; Koscik et al 2014; Racine et al 2016a; Jonaitis et al 2013). All participants were cognitively normal at study entry (MCI, AD, and other forms of dementia were excluded).…”

Section: Methodsmentioning

confidence: 99%

Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer’s disease in late-middle-aged adults

Racine

Merluzzi

Adluru

et al. 2017

Brain Imaging and Behavior

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Alzheimer’s disease (AD) is characterized by substantial neurodegeneration, including both cortical atrophy and loss of underlying white matter fiber tracts. Understanding longitudinal alterations to white matter may provide new insights into trajectories of brain change in both healthy aging and AD, and fluid biomarkers may be particularly useful in this effort. To examine this, 151 late-middle-aged participants enriched with risk for AD with at least one lumbar puncture and two diffusion tensor imaging (DTI) scans were selected for analysis from two large observational and longitudinally followed cohorts. Cerebrospinal fluid (CSF) was assayed for biomarkers of AD-specific pathology (phosphorylated-tau/Aβ42 ratio), axonal degeneration (neurofilament light chain protein, NFL), dendritic degeneration (neurogranin), and inflammation (chitinase-3-like protein 1, YKL-40). Linear mixed effects models were performed to test the hypothesis that biomarkers for AD, neurodegeneration, and inflammation, or two-year change in those biomarkers, would be associated with worse white matter health overall and/or progressively worsening white matter health over time. At baseline in the cingulum, phosphorylated-tau/Aβ42 was associated with higher mean diffusivity (MD) overall (intercept) and YKL-40 was associated with increases in MD over time. Two-year change in neurogranin was associated with higher mean diffusivity and lower fractional anisotropy overall (intercepts) across white matter in the entire brain and in the cingulum. These findings suggest that biomarkers for AD, neurodegeneration, and inflammation are potentially important indicators of declining white matter health in a cognitively healthy, late-middle-aged cohort.

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“…To verify the diagnosis of AD in the parent, parental medical records, autopsy reports, or results of the dementia questionnaire (Kawas, Segal, Stewart, Corrada, & Thal, 1994) were obtained and reviewed by a multidisciplinary diagnostic consensus conference (Jonaitis et al, 2013; Koscik et al, 2014; Sager et al, 2005). Absence of FH of AD was verified through detailed medical history surveys and phone interview with the participants.…”

Section: Methodsmentioning

confidence: 99%

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

Nicholas

Dowling

Racine

et al. 2017

J Int Neuropsychol Soc

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Objectives The purpose of this study was to investigate the longitudinal trajectory of self- and informant-subjective cognitive complaints (SCC), and to determine if SCC predict longitudinal changes in objective measures (OM) of cognitive function. Methods The study included healthy and cognitively normal late middle-aged adults enriched with a family history of AD who were evaluated at up to three visits over a 4-year period. At each visit (Visit 1–3), self- and informant-SCC and OM were evaluated. Linear mixed models were used to determine if the longitudinal rate of change of self- and informant-SCC were associated with demographic variables, depressive symptoms, family history (FH), and apolipoprotein epsilon 4 (APOE4) status. The same modeling approach was used to examine the effect of Visit 1 SCC on longitudinal cognitive change after controlling for the same variables. Results At Visit 1, more self-SCC were associated with fewer years of education and more depressive symptoms. SCC were also associated with poorer performance on cognitive measures, such that more self-SCC at Visit 1 were associated with poorer performance on memory and executive functioning measures at Visit 1, while more informant-SCC were associated with faster rate of longitudinal decline on a measure of episodic learning and memory. FH and APOE4 status were not associated with SCC. Discussion Self- and informant-SCC showed an association with OM, albeit over different time frames in our late middle-aged sample. Additional longitudinal follow-up will likely assist in further clarifying these relationships as our sample ages and more pronounced cognitive changes eventually emerge.

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Cognitive activities and cognitive performance in middle-aged adults at risk for Alzheimer’s disease.

Cited by 55 publications

References 66 publications

Atividades avançadas de vida diária e incidência de declínio cognitivo em idosos: Estudo SABE

Atividades avançadas de vida diária e incidência de declínio cognitivo em idosos: Estudo SABE

Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer’s disease in late-middle-aged adults

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

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