Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study

Martins, Isabel Pavão; Maruta, Carolina; Alves, Pedro; Loureiro, Clara; Morgado, Joana; Tavares, Joana; Gil‐Gouveia, Raquel

doi:10.1186/s10194-020-01100-x

Cited by 23 publications

(29 citation statements)

References 61 publications

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“…However, it is worth mentioning a recent study showing that migraine and non-migraine headache are not associated with increasing risk of dementia or cognitive decline at an older age although subjects with migraine have more cognitive complaints. 38 However, we did not find a correlation between the measures of migraine severity and efficiency of executive function. Previous studies [39][40][41] have reported similar findings in 42 These genetic polymorphisms were also reported to be related to the susceptibility for migraine, although evidences for such an association were inconsistent.…”

Section: Discussioncontrasting

confidence: 69%

Attention Impairment During the Interictal State in Migraineurs without Aura: A Cross-Sectional Study

Chen¹,

Dong²,

Gu³

et al. 2021

JPR

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Background and Purpose: Migraine suffering is more than the onset of head pain. The broad non-painful clinical symptoms associated with migraine are not well recognized. Recent researches support that migraineurs suffer attention deficits, but these findings are not conclusive. The purpose of our study was to assess whether patients with migraine without aura (MwoA) during the interictal period have attention impairment and to identify the migraine characteristics related to attention deficits. Methods: We enrolled subjects with MwoA during the interictal period and healthy controls matched for age, gender, and education level in this cross-sectional study. The attention network test (ANT) and a battery of neuropsychological tests, including the trail-making test (TMT), the digit span test (DST), and the Stroop test, were administered to the participants during the headache-free period. Results: Forty-four subjects with MwoA (4 males, 40 females) and 20 controls matched for age, gender, and literacy education were included. Patients in MwoA were more anxious (P = 0.007) and depressed (P = 0.001) than healthy subjects. Significant differences between the two groups were detected in the executive network (P = 0.006) but not in the alerting and orienting networks of ANT. Mean reaction time of ANT in the MwoA group was significantly longer than that in the control group (P = 0.028). Patients showed worse performance on DST-forward (P < 0.001), DST-backward (P < 0.001), DS Total (P < 0.001), TMT-A (P < 0.001), TMT-B (P < 0.001) and TMT-d (P = 0.002). Differences found in executive functions between the two groups were unrelated to gender, age, literacy, anxiety, and depression. Multiple regression analysis revealed no relation between clinical characteristics of headache and scores on the executive function with MwoA. Conclusion:Our study suggested that patients in MwoA present worse performances on the executive control of attention networks during the headache-free period, which appear not be associated with measures of migraine severity. Although more studies are needed in this area, our results could be useful to find specific neuropsychological biomarker for migraine pathophysiology.

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Section: Discussioncontrasting

confidence: 69%

Attention Impairment During the Interictal State in Migraineurs without Aura: A Cross-Sectional Study

Chen¹,

Dong²,

Gu³

et al. 2021

JPR

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“…The overlap of potential biological mechanisms between migraine and dementia, such as neuroinflammation, brain microstructural changes, and subcortical white matter abnormalities, 5‐8 indicates that migraine may increase the risk of dementia. However, current studies that reported an association between migraine and dementia demonstrated inconsistent associations 9,10 …”

Section: Introductionmentioning

confidence: 68%

Meta‐analysis of association between migraine and risk of dementia

Wang

et al. 2021

Acta Neuro Scandinavica

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Dementia is a common neurodegenerative disease that mainly affects geriatric individuals. It is estimated that as many as 46 million people worldwide have been diagnosed with dementia. 1 As the global population ages, the incidence rate of dementia will continue to rise. 2 However, there is no effective treatment for this condition. Thus, early identification and intervention of dementia-related risk factors may be a way to prevent its development.Migraine is a common neurological condition characterized by recurrent episodes of headache, nausea, vomiting, and/or visual and other aura. 3 Epidemiological investigations have shown that migraine affected around 1.04 billion people of all ages worldwide. 4 The overlap of potential biological mechanisms between migraine and dementia, such as neuroinflammation, brain microstructural changes, and subcortical white matter abnormalities, [5][6][7][8] indicates that migraine may increase the risk of dementia. However, current studies that reported an association between migraine and dementia demonstrated inconsistent associations. 9,10

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“…In recent studies, subjective cognitive complaint scores tended to increase with the frequency of migraines with aura, and this interrelation is influenced by depression severity [38]. In a five-year longitudinal study, migraine was not associated with an increased risk of dementia or cognitive decline in older age, but individuals with migraines had more subjective cognitive complaints and depressive symptoms than the control patients did [39].…”

Section: Discussionmentioning

confidence: 93%

Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine

Lee

Song

et al. 2021

JCM

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Neuroimaging and neuropsychological investigations have indicated that migraineurs exhibit frontal lobe-related cognitive impairment. We investigated whether orbitofrontal and dorsolateral functioning differed between individuals with episodic migraine (EM) and chronic migraine (CM), focusing on orbitofrontal dysfunction because it is implicated in migraine chronification and medication overuse headache (MOH) in migraineurs. This cross-sectional study recruited women with CM with/without MOH (CM + MOH, CM − MOH), EM, and control participants who were matched in terms of age and education. We conducted neuropsychological assessments of frontal lobe function via the Trail Making Test (TMT) A and B, the Wisconsin Card Sorting Test (WCST), and the Iowa Gambling Task (IGT). We enrolled 36 CM (19 CM + MOH, 17 CM–MOH), 30 EM, and 30 control participants. The CM patients performed significantly (p < 0.01) worse on the TMT A and B than the EM patients and the control participants. The WCST also revealed significant differences, with poorer performance in the CM patients versus the EM patients and the control participants. However, the net scores on the IGT did not significantly differ among the three groups. Our findings suggest that the CM patients exhibited frontal lobe dysfunction, and, particularly, dorsolateral dysfunction. However, we found no differences in frontal lobe function according to the presence or absence of MOH.

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Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study

Cited by 23 publications

References 61 publications

Attention Impairment During the Interictal State in Migraineurs without Aura: A Cross-Sectional Study

Attention Impairment During the Interictal State in Migraineurs without Aura: A Cross-Sectional Study

Meta‐analysis of association between migraine and risk of dementia

Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine

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