Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial

Use of the ketogenic diet to manage refractory epilepsy in CDKL5 disorder: Experience of >100 patients

“…Previous human and mouse studies on autism spectrum disorder have described positive effects of KD in aspects of cognition and social functioning. [29][30][31] These improvements have also been reported in prospective Over time, she had daily seizures including brief tonic seizures in clusters, spasms, myoclonic seizures, hypermotor seizures, and focal seizures with an abnormal smile. She initiated oral ketogenic diet at 7 months of age, and had initially an approximately 50% reduction in seizure frequency.…”

“…27,28 Greater rates of seizure response have also been reported in formula feeding as compared to solid meals (59% vs. 27%, at 12 months of treatment). [29][30][31] These improvements have also been reported in prospective More than a quarter of individuals with the CDKL5 disorder will require gastrostomy feeding secondary to poor oral intake.…”

Diettbehandling av epilepsi

“…Ijff and collaborators found that the diet has positive effects on the cognitive functions of children and adolescents (23). This is consistent with our own experience from work with children and adults.…”

β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle

“…Recent discoveries have revealed that ketones, such as acetoacetate and its precursor β-hydroxybutyrate (β-HB), are not only viable fuel sources for all cells with mitochondria, including the brain [1] but are also legitimate signaling molecules, eliciting advantageous changes in inflammation [2], cognition [3,4], oxidative stress [5] and more. Beyond pathology, ketones may also be a relevant metabolic fuel in the context of physical activity, improving athletic performance [6] and myocardial adenosine triphosphate (ATP) generation [7].…”