Cognitive and behavioral outcomes in benign childhood epilepsy with centrotemporal spikes

Vannest, Jennifer; Tenney, Jeffrey R.; Gelineau‐Morel, Rose; Maloney, Thomas; Glauser, Tracy A.

doi:10.1016/j.yebeh.2015.01.041

Cited by 98 publications

(116 citation statements)

References 88 publications

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“…2 The seizures resolve usually spontaneously until puberty. 4 These studies used a multitude of neuropsychological test methods, limiting comparability. 3 These findings have been supported by many subsequent studies.…”

Section: Introductionmentioning

confidence: 99%

“…4 These studies used a multitude of neuropsychological test methods, limiting comparability. 4,7,8 It should be noted that there are some "atypical" variants of BECTS (eg, Landau-Kleffner syndrome [LKS], continuous spike and waves during slow sleep [CSWS]) which are clearly associated with neurocognitive impairments. Correction for multiple testing is not always performed, leading to an overconfident reporting of in fact false positive results.…”

Section: Introductionmentioning

confidence: 99%

“…5 It is well accepted that similar procedures result in unsound interpretations. 4 The identification of a correlation between the grade of EEG pathology and the neuropsychological performance of the patients might suggest the use of antiepileptic drugs based on EEG features alone. There is, however, general acceptance of the fact that children with BECTS are at risk for cognitive or behavioral complications.…”

Section: Introductionmentioning

confidence: 99%

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Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

et al. 2018

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“…The impact of IEDs on cognition is controversial [9-11]. Generalized IEDs have been shown to transiently impair specific cognitive functions in some people with epilepsy (e.g.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of epileptiform discharges in healthy 11- and 12-year-old children

Grant

Chau

Arya

et al. 2016

Epilepsy & Behavior

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We sought to determine the prevalence of interictal epileptiform discharges (IEDs) in healthy 11 and 12-year-old children. Sixth grade students with no history of seizure, or neurologic or psychiatric disease were enrolled in a longitudinal physical activity intervention study. Per study protocol, each student had two EEG recordings approximately 6 months apart. Epileptiform discharges were present in 4 (2.9%) of 140 students: centrotemporal in three and generalized in one. In three children the discharges were still present six months later. None of the children had developed seizures a minimum of one year after the second EEG. These results are consistent with those of two landmark European studies performed nearly a half century ago, before the modern era of digital EEG. Healthy 11 and 12-year-old children with no history of seizure may have centrotemporal or generalized epileptiform discharges on EEG, which can persist for at least 6 months. Based on both our results and those of the two prior European studies, such discharges, if found incidentally in otherwise healthy children in this age group, should not prompt further evaluation or treatment.

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“…For instance, benign epilepsy with centrotemporal spikes typically occurs between the age of 3 and 14 years and resolves by the age 17 years despite the incidence of cognitive and behavioral disorders [56]. By contrast, Lennox-Gastaut syndrome begins between the age of 1 and 6 years, with seizures that generally do not respond well to treatment [57].…”

Section: Disease Progression and Maturationmentioning

confidence: 99%

Pharmacotherapy in pediatric epilepsy: from trial and error to rational drug and dose selection – a long way to go

Dijkman

Álvarez-Jiménez

Danhof

et al. 2016

Expert Opinion on Drug Metabolism & Toxicology

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Introduction: Whereas ongoing efforts in epilepsy research focus on the underlying disease processes, the lack of a physiologically based rationale for drug and dose selection contributes to inadequate treatment response in children. In fact, limited information on the interindividual variation in pharmacokinetics and pharmacodynamics of anti-epileptic drugs (AEDs) in children drive prescription practice, which relies primarily on dose regimens according to a mg/kg basis. Such practice has evolved despite advancements in pediatric pharmacology showing that growth and maturation processes do not correlate linearly with changes in body size. Areas covered: In this review we aim to provide 1) a comprehensive overview of the sources of variability in the response to AEDs, 2) insight into novel methodologies to characterise such variation and 3) recommendations for treatment personalisation. Expert opinion: The use of pharmacokinetic-pharmacodynamic principles in clinical practice is hindered by the lack of biomarkers and by practical constraints in the evaluation of polytherapy. The identification of biomarkers and their validation as tools for drug development and therapeutics will require some time. Meanwhile, one should not miss the opportunity to integrate the available pharmacokinetic data with modeling and simulation concepts to prevent further delays in the development of personalised treatments for pediatric patients.

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Cognitive and behavioral outcomes in benign childhood epilepsy with centrotemporal spikes

Cited by 98 publications

References 88 publications

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology

Prevalence of epileptiform discharges in healthy 11- and 12-year-old children

Pharmacotherapy in pediatric epilepsy: from trial and error to rational drug and dose selection – a long way to go

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