Cognitive and behavioural findings in children with frontal lobe epilepsy

Braakman, Hilde M. H.; IJff, Dominique M.; Vaessen, Maarten J.; Hall, Mariette H. J. A. Debeij‐van; Hofman, Paul; Backes, Walter H.; Vles, Johan S.H.; Aldenkamp, Albert P.

doi:10.1016/j.ejpn.2012.05.003

Cited by 49 publications

(66 citation statements)

References 19 publications

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“…Many studies have found dysfunction in attention [29][30][31], memory [32,33], and executive functions [29]. There are also studies that have found dysfunction in visuospatial [34] and verbal skills [30].…”

Section: Neurocognitive Performance In Children With Epilepsymentioning

confidence: 96%

Relationship between social competence and neurocognitive performance in children with epilepsy

Raud

Kaldoja

Kolk

2015

Epilepsy & Behavior

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Section: Neurocognitive Performance In Children With Epilepsymentioning

confidence: 96%

Relationship between social competence and neurocognitive performance in children with epilepsy

Raud

Kaldoja

Kolk

2015

Epilepsy & Behavior

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“…Growing evidence suggests IEDs can affect cognitive performance [4, 5], and this knowledge is of critical importance to those assessing cognition in epilepsy. Our cases indicate that even a gross knowledge of presence or absence of IEDs can be helpful in understanding cognitive performance.One limitation of this study involved our inability to re-review EEG data due to the retrospective, clinical nature of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies also demonstrate that effects on function worsen with longer duration of IED discharges [4, 8]. …”

Section: 1 Research Demonstrating the Effects Of Interictal Epilepmentioning

confidence: 99%

“…It has been controversial whether interictal epileptiform discharges (IEDs) affect cognitive function [1–3], yet growing evidence suggests that they may [4–6]. We review a broad array of studies with bearing on this topic, and we report two cases whose preoperative neuropsychological evaluations were meaningfully affected by IEDs, and in whom significant performance improvements were observed when evaluated without active IEDs.…”

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confidence: 99%

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Interictal epileptiform discharge effects on neuropsychological assessment and epilepsy surgical planning

Drane

Ojemann

Kim

et al. 2016

Epilepsy & Behavior

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Both animal and human research suggests interictal epileptiform discharges (IEDs) may affect cognition, although the significance of such findings remains controversial. We review a wide range of literature with bearing on this topic, and present relevant epilepsy surgery cases, which suggest the effects of IEDs may be substantial and informative for surgical planning. In the first case, we present an epilepsy patient with left anterior temporal lobe (TL) seizure onset who experienced frequent IEDs during preoperative neuropsychological assessment. Cognitive results strongly lateralized to the left TL. Because the patient failed performance validity tests and appeared amnestic for verbal materials inconsistent with his work history, selected neuropsychological tests were repeated 6 weeks later. Scores improved one to two standard deviations over the initial evaluation, and because of this improvement, were only mildly suggestive of left TL impairment. The second case involves another patient with documented left TL epilepsy who experienced epileptiform activity while undergoing neurocognitive testing and simultaneous ambulatory EEG recording. This patient’s verbal memory performance was impaired during the period that IEDs were present but near normal when such activity was absent. Overall, although the presence of IEDs may be helpful in confirming laterality of seizure onset, frequent IEDs might disrupt focal cognitive functions, and distort accurate measurement of neuropsychological ability, interfering with accurate characterization of surgical risks and benefits. Such transient effects on daily performance may also contribute to significant functional compromise. We include a discussion of the manner in which IED effects during presurgical assessment can hinder individual patient presurgical planning as well as distort outcome research (e.g., IEDs occurring during presurgical assessment may lead to an underestimation of postoperative neuropsychological decline).

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“…These cognitive impairments often cover a broad range of cognitive domains and frequently result in a need for special education (1,2). The etiology of cognitive impairment in children with FLE is unknown, and correlations with clinical epilepsy characteristics remain inconclusive (1,2).…”

Section: Introductionmentioning

confidence: 99%

Pediatric frontal lobe epilepsy: white matter abnormalities and cognitive impairment

et al. 2013

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Cognitive and behavioural findings in children with frontal lobe epilepsy

Cited by 49 publications

References 19 publications

Relationship between social competence and neurocognitive performance in children with epilepsy

Relationship between social competence and neurocognitive performance in children with epilepsy

Interictal epileptiform discharge effects on neuropsychological assessment and epilepsy surgical planning

Pediatric frontal lobe epilepsy: white matter abnormalities and cognitive impairment

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