Cognitive and Psychological Impacts of Congenital Corpus Callosum Disorders in Adults: A Scoping Review

Abstract

Objectives Support for adults with congenital corpus callosum disorders (CCDs) is impeded by poor understanding of the impacts of a CCD on day-to-day functioning and quality of life. This scoping review examines existing literature to establish the evidence-based impacts of congenital CCDs in adults and identify gaps to inform future research, policy development, and service delivery. Methods We conducted searches in Scopus, Medline Ovid, PsycInfo, Discovery, and ERIC. Studies meeting selection criteria were peer-reviewed, in English, published from 1980 to 2021, reported predominantly on participants 16 years or older who were diagnosed with a CCD by magnetic resonance imaging (MRI). Results The thirty-eight included articles comprised 14 single/dual participant case studies and 24 group studies, comparing adults with a CCD with normative data or matched controls. Although most participants were of average IQ, CCDs affected day-to-day executive functioning, social interaction, and meeting expectations of adulthood. Cognitive impacts included difficulties with learning and memory, linguistic and emotional processing, and complex reasoning, with functional capacity typically decreasing as tasks and situations increased in complexity. Psychological impacts pertaining to feelings, emotions, and social awareness were reported in addition to associated mental health, psychiatric mood, and developmental and psychotic disorders including autism, anxiety, depression, and schizophrenia. Conclusions Impacts were extremely heterogenous, presenting interwoven challenges to learning, executive functioning, social interaction, and mental health. Knowledge of these circumstances is vital for adults with CCDs, professionals, and family members to ensure appropriate services and support are available to promote good quality, inclusive lives for all adults with a CCD.

Mir137 Polygenic Risk for Schizophrenia and Ephrin-Regulated Pathway: Role in Lateral Ventricles and Corpus Callosum Volume

“…Novel SNP-based heritability estimates of the CC subregions and CC:LV ratios in particular, indicate high heritability of the endophenotypes, with the highest heritability for the CC:LV ratio. Ventriculomegaly as well as abnormalities of the CC are present in several neuropsychiatric disorders including Alzheimer's disease, dementia, SZ, bipolar disorder, major depression, as well as Parkinson's and Huntington's disease (Duy et al, 2022;Kelly et al, 2018;Maxfield et al, 2023;Thompson et al, 2020), suggest partially common mechanisms of these diseases. While in some instances enlarged LV might index…”

Tatton‐Brown–Rahman syndrome: Novel pathogenic variants and new neuroimaging findings

“…Thus, the neuroimaging findings we highlight in the present study might be useful to better characterize the neuroanatomy of these patients. First, the omnipresent thin transition of the corpus and splenium of the callosum, small posterior fossa, amygdala herniation, and a deep left Sylvian fissure; these minor anomalies might be related to nonverbal reasoning and viso‐spatial difficulties (Barnby et al, 2022; Chen et al, 2011; Frank et al, 2016; Hearne et al, 2019; Maxfield et al, 2023). Furthermore, 3D‐tractography reconstruction revealed anomalies in arcuate and uncinate fasciculi; both tracts appear to play an essential role in social processing, emotional interaction, and cognitive control (Fletcher et al, 2010; Moseley et al, 2016; Olson et al, 2015).…”