Cognitive Behavioral Therapy Program for Cannabis Use Cessation in First-Episode Psychosis Patients: A 1-Year Randomized Controlled Trial

González-Ortega, Itxaso; Echeburúa, Enrique; Alberich, Susana; Bernardo, Miquel; Vieta, Eduard; Pablo, Gonzalo Salazar de; González‐Pinto, Ana

doi:10.3390/ijerph19127325

Cited by 10 publications

(5 citation statements)

References 58 publications

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“…Direct evidence that cannabis cessation can reduce the risk of affective disorders is, however, lacking, and although several interventions appear to be associated with reducing cannabis use in adolescents and healthy adults, they may be less effective in individuals with mental disorders . Although some trials have demonstrated significant improvements in depressive symptoms after a psychosocial intervention to reduce cannabis use, these improvements may be mediated by broader effects of the psychosocial interventions, providing little evidence for the beneficial effects of cannabis cessation itself . Targeted interventions for at-risk individuals are currently hindered by sparse knowledge on factors associated with transition from cannabis use (disorder) to psychiatric disorders, calling for further studies.…”

Section: Discussionmentioning

confidence: 99%

Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder

et al. 2023

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ImportanceCannabis use is increasing worldwide and is suspected to be associated with increased risk of psychiatric disorders; however, the association with affective disorders has been insufficiently studied.ObjectiveTo examine whether cannabis use disorder (CUD) is associated with an increased risk of psychotic and nonpsychotic unipolar depression and bipolar disorder and to compare associations of CUD with psychotic and nonpsychotic subtypes of these diagnoses.Design, Setting, and ParticipantsThis prospective, population-based cohort study using Danish nationwide registers included all individuals born in Denmark before December 31, 2005, who were alive, aged at least 16 years, and living in Denmark between January 1, 1995, and December 31, 2021.ExposureRegister-based diagnosis of CUD.Main Outcome and MeasuresThe main outcome was register-based diagnosis of psychotic or nonpsychotic unipolar depression or bipolar disorder. Associations between CUD and subsequent affective disorders were estimated as hazard ratios (HRs) using Cox proportional hazards regression with time-varying information on CUD, adjusting for sex; alcohol use disorder; substance use disorder; having been born in Denmark; calendar year; parental educational level (highest attained); parental cannabis, alcohol, or substance use disorders; and parental affective disorders.ResultsA total of 6 651 765 individuals (50.3% female) were followed up for 119 526 786 person-years. Cannabis use disorder was associated with an increased risk of unipolar depression (HR, 1.84; 95% CI, 1.78-1.90), psychotic unipolar depression (HR, 1.97; 95% CI, 1.73-2.25), and nonpsychotic unipolar depression (HR, 1.83; 95% CI, 1.77-1.89). Cannabis use was associated with an increased risk of bipolar disorder in men (HR, 2.96; 95% CI, 2.73-3.21) and women (HR, 2.54; 95% CI, 2.31-2.80), psychotic bipolar disorder (HR, 4.05; 95% CI, 3.52-4.65), and nonpsychotic bipolar disorder in men (HR, 2.96; 95% CI, 2.73-3.21) and women (HR, 2.60; 95% CI, 2.36-2.85). Cannabis use disorder was associated with higher risk for psychotic than nonpsychotic subtypes of bipolar disorder (relative HR, 1.48; 95% CI, 1.21-1.81) but not unipolar depression (relative HR, 1.08; 95% CI, 0.92-1.27).Conclusions and RelevanceThis population-based cohort study found that CUD was associated with an increased risk of psychotic and nonpsychotic bipolar disorder and unipolar depression. These findings may inform policies regarding the legal status and control of cannabis use.

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Section: Discussionmentioning

confidence: 99%

Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder

et al. 2023

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“…Given the significant clinical and economic implications of cannabis and tobacco use, our study highlights the promising potential of the Prescinde therapy app as a cost-effective intervention with substantial health benefits. In particular, we have reported benefits in terms of reduced tobacco use at follow-up [10,18]. These findings suggest that the use of the therapy app Prescinde alone could be beneficial for tobacco cessation and increasing physical exercise.…”

Section: Discussionmentioning

confidence: 59%

“…Cognitive behavioral treatment is widely recognized as one of the most effective therapeutic approaches for individuals seeking to quit using these substances [10][11][12]. However, there is a concerning decline in the number of people accessing face-to-face support for these addictions [13].…”

Section: Introductionmentioning

confidence: 99%

“…The treatment for quitting cannabis and/or tobacco use continues to pose challenges (cognitive behavioral therapy, nicotine replacement therapy, or nicotine patches), as indicated by low treatment adherence rates ranging from 13% to 50% [10,17,18], while high treatment relapse rates ranging from 40% to 60%, even as high as 86% [19,20], seem to further compound the issue. Only one in six people with addiction to these substances seek treatment to stop using them.…”

Section: Introductionmentioning

confidence: 99%

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Use of the Therapy App Prescinde for Increasing Adherence to Smoking Cessation Treatment

López-Torrecillas,

Ramírez-Uclés,

Rueda

et al. 2023

Healthcare

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Tobacco use poses major health risks and is a major contributor to causes of death worldwide. Mobile phone-based cessation apps for this substance are gaining popularity, often used as a component of traditional interventions. This study aimed to analyze adherence to an intervention using a mobile phone application (App-therapy Prescinde (v1)) as a function of sociodemographic variables (age, gender, educational level, and profession) as well as the primary activities supported by the app (reducing tobacco or cannabis use and increasing physical exercise). The participants were recruited through the web pages of the Occupational Risk Prevention Service and the Psychology Clinic of the University of Granada during the COVID-19 confinement period. The application’s contents include three components (self-report, motivational phrases, and goal setting). Our findings indicate that being male, being aged between 26 and 62, having a high school education, and being unemployed increase the likelihood of adherence to the Prescinde therapy app three months after usage. Our findings highlight the importance of developing new therapeutic approaches and conducting in-depth studies on the factors associated with adherence to tobacco cessation and cannabis cessation treatments via mobile phone applications.

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“…Furthermore, CBT has been widely used for SUD [64,65] and is being implemented more frequently for patients with psychosis [30,31,66,67]. One study examined a CBT intervention for patients with psychosis and cannabis use [68]. The study showed greater reduction in cannabis use and positive symptoms, as well as improved functioning in the CBT group.…”

Section: Discussionmentioning

confidence: 99%

Substance Use Disorder and Delusional Symptoms in Patients with Psychosis

Penzenstadler,

Chatton,

Lecomte

et al. 2023

Swiss Arch Neurol Psychiatr Psychother

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Backgr Background: ound: Delusional thinking and low belief flexibility are important treatment targets in patients with psychotic disorders. Game-based interventions may improve hypothetical reasoning. As co-occurring substance use disorders (SUD) and psychotic disorders are common, the current study explores whether SUD may have an impact on the change of delusional beliefs in patients with psychosis. Methods: Methods: This study is a secondary analysis of a longitudinal, assessor blinded, randomised controlled trial, in which 172 patients with positive psychosis symptoms were randomised into an intervention targeting belief flexibility. An improvement over time was found in the Peters et al. Delusion Inventory sub-scales and the Brief Psychiatric Rating Scale outcomes in the treatment group. The current study explores whether co-occurring SUD may have an impact on this change. We used a one-way repeated measures analysis of variance (ANOVA) with SUD present (yes vs no) as the between-subject factor and time as the within-subject factor. As 29% of the patients were not investigated for SUD, we also performed a sensitivity analysis in which we examined the undiagnosed participants as a fully-fledged group, allowing the analysis of all 172 participants. Results: Results: There was no significant effect of SUD. However, an overall significant time effect was observed for distress (F = 18.7, p <0.001), conviction (F = 19.8. p <0.001), preoccupation (F = 15.4, p <0.001) and BPRS (F = 6.3, p = 0.002). This means that all patients improved similarly on their reduction of all dimensions regardless of presenting an active SUD or not. The same analysis with a third group labelled "undiagnosed" almost replicated the above results. Conclusions: Conclusions: The presence of concomitant SUD at baseline does not seem to influence treatment outcomes over time concerning delusional beliefs. Therefore, specialised programs for psychotic disorders can be as effective for patients with concurrent SUD as for patients with psychosis only.

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Cognitive Behavioral Therapy Program for Cannabis Use Cessation in First-Episode Psychosis Patients: A 1-Year Randomized Controlled Trial

Cited by 10 publications

References 58 publications

Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder

Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder

Use of the Therapy App Prescinde for Increasing Adherence to Smoking Cessation Treatment

Substance Use Disorder and Delusional Symptoms in Patients with Psychosis

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