2021
DOI: 10.1159/000517074
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Cognitive Behavioral Therapy to Sustain the Antidepressant Effects of Ketamine in Treatment-Resistant Depression: A Randomized Clinical Trial

Abstract: <b><i>Introduction:</i></b> Ketamine has emerged as a rapid-acting antidepressant. While ongoing treatment can prevent relapse, concerns exist regarding long-term exposure. <b><i>Objective:</i></b> We conducted a randomized trial to examine the feasibility and efficacy of cognitive behavioral therapy (CBT) following intravenous ketamine in treatment-resistant depression (TRD). <b><i>Methods:</i></b> Subjects with TRD were recruited and tre… Show more

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Cited by 57 publications
(41 citation statements)
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“…In their subsequent 2021 randomized controlled trial, Wilkinson et al 35 administered 6 IV ketamine (0.5mg/kg over 40 min) sessions over the course of 3 weeks to 42 severely depressed patients. Of the 42 subjects, 28 (66.7%) achieved a response to ketamine as defined as a >50% improvement in depression severity by the end of the last ketamine session.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…In their subsequent 2021 randomized controlled trial, Wilkinson et al 35 administered 6 IV ketamine (0.5mg/kg over 40 min) sessions over the course of 3 weeks to 42 severely depressed patients. Of the 42 subjects, 28 (66.7%) achieved a response to ketamine as defined as a >50% improvement in depression severity by the end of the last ketamine session.…”
Section: Resultsmentioning
confidence: 99%
“… 44 While there were no reported differences in reductions of depression and anxiety scores between the single and multi-dose groups in the above studies, multiple administrations of ketamine seemed to prolong therapeutic effects and resulted in initial non-responders experiencing apparent ketamine-related benefits. 34 , 46 As ketamine non-responders are identifiable, 23 , 34 , 35 , 46 the frequency of ketamine administration during KAP treatments can be further investigated to maximize overall responsiveness.…”
Section: Discussionmentioning
confidence: 99%
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“…To date, ketamine’s utility in enhancing psychotherapy has mainly been explored in smaller studies. One open-label study of 16 patients with TRD found that psychotherapy extended ketamine’s rapid antidepressant effects, though most responders relapsed after ceasing CBT [ 67 ]. A recent follow-up study randomized 28 patients who had achieved response after six ketamine infusions to receive either CBT or treatment as usual [ 67 ].…”
Section: Ketamine-assisted Psychotherapymentioning
confidence: 99%
“…One open-label study of 16 patients with TRD found that psychotherapy extended ketamine’s rapid antidepressant effects, though most responders relapsed after ceasing CBT [ 67 ]. A recent follow-up study randomized 28 patients who had achieved response after six ketamine infusions to receive either CBT or treatment as usual [ 67 ]. After 14 weeks of therapy, the investigators found a moderate, though not statistically significant, improvement in MADRS scores and a significant effect as measured by the Quick Inventory of Depressive Symptomatology, Self-Report 16-Item (QIDS-SR-16) in the CBT group.…”
Section: Ketamine-assisted Psychotherapymentioning
confidence: 99%