Cognitive biomarkers of post-traumatic stress disorder

Palmer, Barton W.

doi:10.1017/s1041610220001544

Cited by 1 publication

(2 citation statements)

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“…This implication should be underscored, as not only may cognition be enhanced, but perhaps the deleterious effect of PTSD leading to dementia can be decreased (Desmarais et al ., 2020). Our paper adds to recent literature by strengthening the indications that PTSD symptoms may indeed be a risk factor for increased late-life cognitive decline (Palmer, 2021; Rutter et al ., 2021). To better understand these results, we examined the added contribution of the associations of interest to the explained variance of cognitive function.…”

Section: Discussionsupporting

confidence: 76%

“…People with PTSD may have cognitive decline, a risk which can be particularly threatening during older age, since cognitive deterioration becomes more common as people grow old (Golier et al ., 2006). However, some prominent issues remain unclear concerning this PTSD-cognitive decline link in older adults (Palmer, 2021). The current study will specifically address three issues, the directionality of this association, its nature, and an underlying mechanism.…”

Section: Introductionmentioning

confidence: 99%

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Reciprocal associations of posttraumatic stress symptoms and cognitive decline in community-dwelling older adults: The mediating role of depression

Cohn‐Schwartz

Shrira

2022

Int. Psychogeriatr.

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Background: People with posttraumatic stress disorder (PTSD) may have cognitive decline, a risk which can be particularly threatening at old age. However, it is yet unclear whether initial cognitive decline renders one more susceptible to subsequent PTSD following exposure to traumatic events, whether initial PTSD precedes cognitive decline or whether the effects are reciprocal. Objective: This study examined the bidirectional longitudinal associations between cognitive function and PTSD symptoms and whether this association is mediated by depressive symptoms. Method: The study used data from two waves of the Israeli component of the Survey of Health, Ageing, and Retirement in Europe (SHARE), collected in 2013 and 2015. This study focused on adults aged 50 years and above (N = 567, mean age = 65.9 years). Each wave used three measures of cognition (recall, fluency, and numeracy) and PTSD symptoms following exposure to war-related events. Data were analyzed using mediation analysis with path analysis. Results: Initial PTSD symptoms predicted cognitive decline in recall and fluency two years later, while baseline cognitive function did not impact subsequent PTSD symptoms. Partial mediation showed that older adults with more PTSD symptoms had higher depressive symptoms, which in turn were linked to subsequent cognitive decline across all three measures. Conclusions: This study reveals that PTSD symptoms are linked with subsequent cognitive decline, supporting approaches addressing this direction. It further indicates that part of this effect can be explained by increased depressive symptoms. Thus, treatment for depressive symptoms may help reduce cognitive decline due to PTSD.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%