Cognitive Changes Associated With Cancer and Cancer Treatment: State of the Science

Ah, Diane Von

doi:10.1188/15.cjon.19-01ap

Cited by 28 publications

(13 citation statements)

References 93 publications

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“…There is accumulating evidence documenting cognitive impairment issues among cancer survivors, but this is mainly dominated by breast cancer survivors. 22 The prevalence of cognitive complaints among Chinese cervical cancer survivors was 64.5%, which is consistent with previous research. 6 As this study was preliminary and adopted a small and non-random sample, epidemiological studies are needed to further quantify the prevalence, impact and extent of cognitive complaints in this study population.…”

Section: Discussionsupporting

confidence: 91%

Cervical cancer survivors’ perceived cognitive complaints and supportive care needs in mainland China: a qualitative study

et al. 2017

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ObjectivesThis study explores Chinese cervical cancer survivors’ perceived cognitive complaints and relevant supportive care needs after primary cancer treatment.DesignThis study utilised a qualitative research design. A semi-structured interview was used to probe cervical cancer patients’ perceived cognitive complaints and supportive care needs.SettingThis study was conducted at a secondary cancer care centre located in South China.Participants31 women with cervical cancer after primary cancer treatment, aged 18–60 years, were purposively selected using non-random sampling procedures.Results31 cervical cancer survivors joined this study. Of these, 20 women (64.5%) reported cognitive complaints after cancer treatment. The most common complaint was loss of concentration (n=17, 85.0%). Perceived contributing factors to these cognitive complaints included chemotherapy (n=15, 75.0%) and ageing (n=8, 40.0%). These cognitive problems most commonly impacted daily living (n=20, 100%). Common supportive care needs included symptom management strategies (n=11, 55.0%) and counselling services (n=8, 40.0%).ConclusionThis study adds new insight into the growing body of research on cognitive complaints by cancer survivors, in particular Chinese cervical cancer survivors. Improved understanding of cognitive complaints could subsequently facilitate the development of relevant therapeutic interventions for prevention as well as the provision of supportive care services, such as educational and counselling services, to reduce cognitive impairment in women with cervical cancer.

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Section: Discussionsupporting

confidence: 91%

Cervical cancer survivors’ perceived cognitive complaints and supportive care needs in mainland China: a qualitative study

et al. 2017

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“…Thus repeated acute stress may be associated with decreased working and recognition memory. An additional study has suggested that cognitive impairment may be due to neurotoxic or microvascular injuries, inflammation, regulatory issues with the hypothalamic-pituitary-adrenal axis that could impact brain hormone concentrations, or increases in the rate of cellular aging, as a result of cancer tumor or treatment [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Mindfulness-based interventions and cognitive function among breast cancer survivors: a systematic review

et al. 2018

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BackgroundBreast cancer survivors have an elevated risk of cognitive impairment compared to age-matched women without cancer. Causes of this impairment are complex, including both treatment and psychological factors. Mindfulness-based interventions, which have been shown to improve cognitive function in the general population, may be one approach to mitigate cognitive impairment in this survivor population. Our objective was to conduct a systematic literature review of studies on the effect of mindfulness-based interventions on cognition among breast cancer survivors.MethodsWe conducted searches of three electronic databases (Scopus, PubMed and Cochrane Database of Systematic Reviews) in September 2017 for studies pertaining mindfulness and cognitive function among breast cancer survivors. Abstracts were manually searched by two reviewers and additional articles were identified through reference lists.ResultsA total of 226 articles were identified through our systematic search and six met inclusion criteria for this review. The reviewed studies lacked consistency in terms of the cognition domains studied (e.g. executive function, recent memory, etc) and in the measures used to assess cognition. Of the included studies, two found no association between mindfulness interventions and cognitive function, two found improvement that was not sustained at the follow-up, and another two found sustained improvement at 2- or 6-months.ConclusionsMindfulness-based interventions have shown some evidence for improving cognition among breast cancer survivors, but further research using validated and comprehensive cognitive assessments is needed. More research is also needed related to the timing, duration and content of mindfulness interventions.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-5065-3) contains supplementary material, which is available to authorized users.

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“… 49 Another interesting aspect is that cancer and cancer treatment on its own can lead to cognitive impairment, which highlights the need for more knowledge and guidelines about the particularities of this group and how it should be treated. 50 …”

Section: Discussionmentioning

confidence: 99%

Comorbid Dementia and Cancer in Residents of Nursing Homes

et al. 2018

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Background:Life expectancy is increasing continuously, which increases the likelihood of developing dementia or cancer. Both dementia and cancer are serious conditions that give manifold symptoms. The interaction of these conditions is however complex and less explored.Objectives:The aim of this study was to identify the prevalence of cancer and differences regarding neuropsychiatric symptoms (NPS) and medication among nursing home (NH) patients with and without dementia and cancer.Methods:This is a cross-sectional study of Norwegian NH patients (N = 1825). Participants were categorized according to degree of dementia (Clinical Dementia Rating > 1) and cancer diagnoses. Differences in NPS and other symptoms, as well as the use of medication, were explored.Results:Eighty-four percent of NH patients had dementia, and 5.5% had comorbid dementia and cancer. Patients with comorbid dementia and cancer received significantly more analgesics compared with patients without cancer but with dementia (P < .05). Compared with patients without dementia but with cancer, patients with comorbid dementia and cancer had significantly more NPS, including sleep disturbances and agitation.Conclusions:Patients with comorbid dementia and cancer receive more analgesics than patients with dementia but still display more agitation and sleep disturbances than patients with cancer and patients with neither dementia nor cancer, suggesting that symptoms may not be treated adequately.Implications for Practice:The results indicate a considerable strain for patients with comorbid dementia and cancer and highlight essential challenges for the clinician who is responsible for treatment and care. Nurses should pay attention to agitation and sleep disturbances among patients with comorbid dementia and cancer.

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Cognitive Changes Associated With Cancer and Cancer Treatment: State of the Science

Abstract: Evidence-based interventions to address cognitive changes after cancer and cancer treatment are limited. However, emerging research has demonstrated that nonpharmacologic treatments, such as cognitive training, are likely to be effective.

Cited by 28 publications

References 93 publications

Cervical cancer survivors’ perceived cognitive complaints and supportive care needs in mainland China: a qualitative study

Cervical cancer survivors’ perceived cognitive complaints and supportive care needs in mainland China: a qualitative study

Mindfulness-based interventions and cognitive function among breast cancer survivors: a systematic review

Comorbid Dementia and Cancer in Residents of Nursing Homes

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