Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele.

Ware, Ashley L.; Kulesz, Paulina A.; Juranek, Jenifer; Cirino, Paul T.; Fletcher, Jack Μ.

doi:10.1037/neu0000350

Cited by 14 publications

(15 citation statements)

References 78 publications

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“…Although SB has a lower-case fatality rate than other neural tube defects, it often results in severe life-long disability and morbidity. Moreover, now that the oldest cohort with SB is nearly 60 years of age, a better understanding of age-related changes across the lifespan is critical to inform and improve clinical care for this population (Dennis, Spiegler, & Hetherington, 2000; Ware, Kulesz, Juranek, Cirino, & Fletcher, 2017).…”

Section: Introductionmentioning

confidence: 99%

Psychological morbidity among adults with cerebral palsy and spina bifida

et al. 2020

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Background Very little is known about the risk of developing psychological morbidities among adults living with cerebral palsy (CP) or spina bifida (SB). The objective of this study was to compare the incidence of and adjusted hazards for psychological morbidities among adults with and without CP or SB. Methods Privately insured beneficiaries were included if they had an International Classification of Diseases, Ninth revision, Clinical Modification diagnostic code for CP or SB (n = 15 302). Adults without CP or SB were also included (n = 1 935 480). Incidence estimates of common psychological morbidities were compared at 4-years of enrollment. Survival models were used to quantify unadjusted and adjusted hazard ratios for incident psychological morbidities. Results Adults living with CP or SB had a higher 4-year incidence of any psychological morbidity (38.8% v. 24.2%) as compared to adults without CP or SB, and differences were to a clinically meaningful extent. Fully adjusted survival models demonstrated that adults with CP or SB had a greater hazard for any psychological morbidity [hazard ratio (HR): 1.60; 95% CI 1.55–1.65], and all but one psychological disorder (alcohol-related disorders), and ranged from HR: 1.32 (1.23, 1.42) for substance disorders, to HR: 4.12 (3.24, 5.25) for impulse control disorders. Conclusions Adults with CP or SB have a significantly higher incidence of and risk for common psychological morbidities, as compared to adults without CP or SB. Efforts are needed to facilitate the development of improved clinical screening algorithms and early interventions to reduce the risk of disease onset/progression in these higher-risk populations.

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Section: Introductionmentioning

confidence: 99%

Psychological morbidity among adults with cerebral palsy and spina bifida

et al. 2020

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“…Central province --1.2 MMC -myelomeningocele tool that allows early diagnosis during the first trimester. 1 Any treatment or management options undertaken during this period must be carried out with much caution, especially in our conservative Muslim culture. We looked at this issue from 2 perspectives, as based on the opinion of the Islamic Fiqh (Jurisprudence) council, under the umbrella of the Muslim world league.…”

Section: Studymentioning

confidence: 99%

“…Epilepsy and low intelligence quotient (IQ) are potential major neurological complications of MMC. 1,2 Moreover, neural tube defects necessitate rehabilitation and multiple subspecialty clinic visits, as well as potential surgeries for bowel, bladder, and leg deformities. This pathology results from a failure of the neural tube to close, which leads to spinal cord exposure, known as spina bifida (SB), of which MMC is the most common type.…”

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confidence: 99%

Review on myelomeningocele management and its current status in Saudi Arabia

Alnaami

Alayad

2019

NSJ

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Major approaches have emerged in the field of myelomeningocele (MMC) management. The prevalence of MMC in Kingdom of Saudi Arabia is 0.44-1.46/1000 births. Nine point seven percent of pregnant Saudi women take folic acid before conception; MMC is estimated to result in 1,417,500 Saudi Riyals (SAR) in lifetime costs per patient. Abortion should be performed cautiously in Muslim countries; another option may be the intrauterine foetal surgical repair of MMC, which has better neuromotor outcomes and reduces the need for ventriculoperitoneal shunt, albeit with a higher risk of obstetric complications. Seven years after intrauterine foetal surgery emerged, there is a need to establish this service in Kingdom of Saudi Arabia. A multidisciplinary approach is required for MMC Review Article patients; surgical closure should be carried out within 72 hours after birth to reduce the risk of infection. Advancing MMC care allows patients to survive to adulthood, and action must be taken to improve the quality of MMC care in Kingdom of Saudi Arabia.

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“…Furthermore, according to several studies many other individuals with SB show impaired executive functions (EF) 1 , which become more evident when performing more complex activities ( 5 ). Impaired working memory ( 9 ), a part of EF ( 8 ), and prospective memory ( 10 ) are also common, as well as attention disorders ( 11 ), impaired processing speed, timing deficits ( 5 ), problems with time management ( 12 ) and with getting things done ( 13 ). Impaired visuospatial function is also common ( 11 ).…”

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confidence: 99%

“…These cognitive impairments can be observed in childhood and become more evident during adolescence and adulthood, when activities of daily living (especially taking care of your own household), education, work and relations put increased demands on the person ( 14 ). Several studies found that cognitive impairments in individuals with SB do not decrease with maturity, but persist into adulthood ( 9 , 14 ). Furthermore, impairments in prospective memory have also been shown to increase for persons over 32 years of age ( 10 ).…”

mentioning

confidence: 99%

Cognitive function and performance of everyday activities in adults with spina bifida

Riedel¹,

Hagman²,

Green³

et al. 2021

J Rehabil Med

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Background and objective Individuals with spina bifida often have cognitive impairments leading to difficulties in education and daily activities. The aims of this study were to explore cognitive impairments in adults with spina bifida and to consider associations between impairments, educational outcome and performance of daily activities, comparing individuals with and without intellectual disability. Methods Data were collected on 35 adults with spina bifida via cognitive tests and Assessment of Motor and Process Skills (AMPS). Participants were divided into 3 groups: individuals without intellectual disability who completed compulsory education (NID-C); those without intellectual disability, who failed to successfully pass compulsory education (NID-F); and those with intellectual disability failed to successfully pass compulsory education (ID-F). Results All individuals with intellectual disability failed to successfully pass compulsory education (group ID-F) and had poorer scores across almost all measures than group NID-F and significantly poorer scores than group NID-C. All except 6 individuals scored below cut-off levels for effort and safety on both AMPS motor and process scales; more significant associations were seen between the cognitive tests and the motor rather than process scale. Conclusion Cognitive impairments, irrespective of intellectual disability, impact on the performance of everyday activities and on educational achievement, and thus need to be considered in assessments and interventions to improve outcomes and promote independence in people with spina bifida. LAY ABSTRACT Individuals with spina bifida often have cognitive impairments, resulting in difficulties in performing their everyday life activities at home, in education, training and social life. These difficulties are often not recognized, and the individuals do not receive the support they need from society. This study investigated the relationship between cognitive impairments, school achievements and performance of daily life activities of 35 adults with spina bifida. The study examined whether individuals had an intellectual disability, and whether they had completed compulsory education, and compared this with their cognitive function and performance in everyday activities. The results confirm that individuals with cognitive impairments, even those without intellectual disabilities, often have considerable difficulties in school achievements, and performance of daily life activities, reducing their ability to live independently.

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Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele.

Cited by 14 publications

References 78 publications

Psychological morbidity among adults with cerebral palsy and spina bifida

Psychological morbidity among adults with cerebral palsy and spina bifida

Review on myelomeningocele management and its current status in Saudi Arabia

Cognitive function and performance of everyday activities in adults with spina bifida

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