Cognitive correlates of Aβ deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Reduction of Synaptojanin 1 Accelerates Aβ Clearance and Attenuates Cognitive Deterioration in an Alzheimer Mouse Model

“…Previously studies have shown that one strain of human Swedish APP and FAD-linked PS1 double mutant transgenic mice (Swedish APP/PS1 M146V) exhibit deficits in the novel object recognition memory task (22). Similarly, our double transgenic mice (APP/…”

“…Novel Object Recognition Task-Human Swedish APP and FAD-linked PS1 mutant transgenic mice show a deficit in the novel object recognition memory task (22). Littermates at 4 -5 months of age were tested in novel object recognition, with onset of the exploration time defined as the moment the head of the animal approached the object within a 2-cm radius.…”

MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity

“…Transgenic Mice-TASTPM mice, which are transgenic mice overexpressing the 695-amino acid isoform of human amyloid precursor protein (APP695) harboring the Swedish double familial Alzheimer disease mutation (K670N,M671L) and human presenilin-1 harboring the familial mutation M146V were generated and maintained at GlaxoSmithKline as described in detail previously (25,26). In this double transgenic line, both transgenes are under the control of the Thy-1 regulatory cassette, which directs expression to the cerebral cortex, amygdala, dentate gyrus, CA1-CA3, and the cerebellum.…”

“…TASTPM mice are a double transgenic line that overexpress mutant forms of human amyloid precursor protein and presenilin-1 specifically in the CNS, resulting in progressive amyloid deposition and pathology in the brain (25,26). Both transgenes are under the control of the Thy-1 regulatory cassette, which directs expression to the cerebral cortex, amygdala, dentate gyrus, CA1-CA3, and the cerebellum (25,26). Gene expression studies utilized cortical and cerebellar tissues from WT and TASTPM mice.…”

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

“…APPswe mice were backcrossed onto a pure C57BL/6 background before crossing with PS1 mice to produce double heterozygous mutant mice (APP/PS1) [18]. Given the gender-specific differences in the progression of Ab deposition, we used only male mice in the present study.…”