Cognitive decline in older adults with a history of traumatic brain injury

Moretti, Laura; Cristofori, Irène; Weaver, Starla M.; Chau, Aileen; Portelli, Jaclyn N.; Grafman, Jordan

doi:10.1016/s1474-4422(12)70226-0

Cited by 212 publications

(166 citation statements)

References 137 publications

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“…A recent report suggests that cognitive reserve may mitigate cognitive decline in older individuals with earlier life TBI. 38 Future research examining the roles of cognitive reserve, genetics, and environmental factors in determining resilience to clinical manifestations and the progression of p-tau pathology will help elucidate the pathobiology of CTE.…”

Section: Resultsmentioning

confidence: 99%

Clinical presentation of chronic traumatic encephalopathy

Daneshvar²,

et al. 2013

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Objective: The goal of this study was to examine the clinical presentation of chronic traumatic encephalopathy (CTE) in neuropathologically confirmed cases.Methods: Thirty-six adult male subjects were selected from all cases of neuropathologically confirmed CTE at the Boston University Center for the Study of Traumatic Encephalopathy brain bank. Subjects were all athletes, had no comorbid neurodegenerative or motor neuron disease, and had next-of-kin informants to provide retrospective reports of the subjects' histories and clinical presentations. These interviews were conducted blind to the subjects' neuropathologic findings.Results: A triad of cognitive, behavioral, and mood impairments was common overall, with cognitive deficits reported for almost all subjects. Three subjects were asymptomatic at the time of death. Consistent with earlier case reports of boxers, 2 relatively distinct clinical presentations emerged, with one group whose initial features developed at a younger age and involved behavioral and/or mood disturbance (n 5 22), and another group whose initial presentation developed at an older age and involved cognitive impairment (n 5 11). Conclusions:

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Section: Resultsmentioning

confidence: 99%

Clinical presentation of chronic traumatic encephalopathy

Daneshvar²,

et al. 2013

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“…Another paper recognizes a possible link between TBI and dementia, but asserts that additional work is necessary to determine whether the dementia associated with TBI is consistent with clinically diagnosed AD or other types of dementia [56]. Other authors question whether a direct link exists between TBI and dementia, and instead suggest that a history of TBI in late life, combined with the brain changes associated with normal aging, might lead to more rapid cognitive decline in older adults [57]. The final review paper, the met inclusion criteria, was a systematic review which found insufficient evidence to draw any conclusion about a potential risk for dementia after mTBI [58].…”

Section: • Studies Reporting a Conditional Relationship Between Tbi Andmentioning

confidence: 99%

Traumatic Brain Injury As a Risk Factor for Alzheimer’s Disease: Current Knowledge and Future Directions

Dams-O’Connor

Guetta

Hahn-Ketter

et al. 2016

Neurodegener. Dis. Manag.

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There is growing concern about the late effects of traumatic brain injury (TBI). This scoping review summarizes clinical research from the past 10 years that evaluates the relationship between TBI and Alzheimer's disease. This review identified five studies that found increased risk for dementia after TBI, two studies that found no increased risk and four studies that found a relationship only under certain conditions or in specified subsamples. Methodological differences across studies preclude direct comparison of results, and discrepant findings elucidate the complex course of post-TBI neurodegeneration. We discuss the factors that influence the strength and direction of the relationship between TBI and Alzheimer's disease, and the implications of this body of research for patient care and future research.

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“…Socioeconomic status has been associated with cognitive reserve, and research has shown that persons with higher cognitive reserve are less susceptible to cognitive deficits after TBI. [51][52][53] The theory of cognitive reserve posits that an individual's experiences affect the efficiency of their neural and cognitive networks, such that those with enriching life histories are protected against cognitive decline.…”

Section: Rabinowitz Et Almentioning

confidence: 99%

Prevalence and Predictors of Poor Recovery from Mild Traumatic Brain Injury

Rabinowitz

McCauley

et al. 2015

Journal of Neurotrauma

114

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Although most patients with mild traumatic brain injury (mTBI) recover within 3 months, a subgroup of patients experience persistent symptoms. Yet, the prevalence and predictors of persistent dysfunction in patients with mTBI remain poorly understood. In a longitudinal study, we evaluated predictors of symptomatic and cognitive dysfunction in adolescents and young adults with mTBI, compared with two control groups-patients with orthopedic injuries and healthy uninjured individuals. Outcomes were assessed at 3 months post-injury. Poor symptomatic outcome was defined as exhibiting a symptom score higher than 90% of the orthopedic control (OC) group, and poor cognitive outcome was defined as exhibiting cognitive performance poorer than 90% of the OC group. At 3 months post-injury, more than half of the patients with mTBI (52%) exhibited persistently elevated symptoms, and more than a third (36.4%) exhibited poor cognitive outcome. The rate of high symptom report in mTBI was markedly greater than that of typically developing (13%) and OC (17%) groups; the proportion of those with poor cognitive performance in the mTBI group exceeded that of typically developing controls (15.8%), but was similar to that of the OC group (34.9%). Older age at injury, female sex, and acute symptom report were predictors of poor symptomatic outcome at 3 months. Socioeconomic status was the only significant predictor of poor cognitive outcome at 3 months.

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Cognitive decline in older adults with a history of traumatic brain injury

Cited by 212 publications

References 137 publications

Clinical presentation of chronic traumatic encephalopathy

Clinical presentation of chronic traumatic encephalopathy

Traumatic Brain Injury As a Risk Factor for Alzheimer’s Disease: Current Knowledge and Future Directions

Prevalence and Predictors of Poor Recovery from Mild Traumatic Brain Injury

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