Cognitive deficits in patients with a chronic vestibular failure

Popp, Pauline; Wulff, Melanie; Finke, Kathrin; Ruehl, Ria Maxine; Brandt, Thomas; Dieterich, Marianne

doi:10.1007/s00415-016-8386-7

Cited by 126 publications

(116 citation statements)

References 41 publications

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“…68 Comparing the flexible strategy to the undetermined strategy, a flexible strategist had greater 269 odds of being male, having a high education level, and being older in age (in reference to the 270 youngest age group of [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Comparing the flexible strategy to the orientation strategy, a 271 flexible strategist had greater odds of being male, having a high education level, and living in 272 a lower-density urban area with 100,000 up to 500,000 inhabitants per region.…”

Section: ~~~~~~~~~ Table 3 About Here (Separate File) ~~~~~~~2mentioning

confidence: 99%

“…Vestibular 75 dysfunction also leads to a decrease in hippocampal size and an associated decrease in 76 navigational ability [3,19,20]. This suggests that Alzheimer's disease, dementia and vestibular 77 dysfunction may specifically impair the ability for persons to use the orientation strategy.78 Alternatively, recent evidence suggests that vestibular dysfunction strongly influences 79 cognitive function and navigation in general [3,18,21,22]. It was associated with a decrease in 80 cognitive function equivalent to adding five years of age [18], suggesting that vestibular 81 dysfunction may affect both navigation strategies.82 Although we have started to understand the factors that affect strategy use in individuals, there 83 is also much we do not know.…”

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confidence: 99%

“…78 Alternatively, recent evidence suggests that vestibular dysfunction strongly influences 79 cognitive function and navigation in general [3,18,21,22]. It was associated with a decrease in 80 cognitive function equivalent to adding five years of age [18], suggesting that vestibular 81 dysfunction may affect both navigation strategies.…”

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confidence: 99%

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Who gets lost and why: A representative cross-sectional survey on sociodemographic and vestibular determinants of wayfinding strategies

Ulrich

Grill

Flanagin

2018

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2 When we think of our family and friends, we probably know someone who is good at finding 3 their way and someone else that easily get lost. We still know little about the biological and 4 environmental factors that influence our navigational ability. Here, we investigated the 5 frequency and sociodemographic determinants of wayfinding and their association with 6 vestibular function in a representative cross-sectional sample (N = 783) of the adult German-7 speaking population. Wayfinding was assessed using the Wayfinding Strategy Scale, a self-8 report scale that produces two scores for each participant representing to what degree they rely 9 on route-based or orientation (map-based) strategies. We were interested in the following 10 research questions: (1) the frequency and determinants of wayfinding strategies in a population-11 based representative sample, (2) the relationship between vestibular function and strategy 12 choice and (3) how sociodemographic factors influence general wayfinding ability as measured 13 using a combined score from both strategy scores. Our linear regression models showed that 14 being male, having a higher education, higher age and lower regional urbanization increased 15 orientation strategy scores. Vertigo/dizziness reduced the scores of both the orientation and the 16 route strategies. Using a novel approach, we grouped participants by their combined strategy 17 scores in a multinomial regression model, to see whether individuals prefer one strategy over 18 the other. The majority of individuals reported using either both or no strategy, instead of 19 preferring one strategy over the other. Young age and reduced vestibular function were 20 indicative of using no strategy. In summary, wayfinding ability depends on both biological and 21 environmental factors; all sociodemographic factors except income. Over a third of the 22 population, predominantly under the age of 35, does not successfully use either strategy. This 23 represents a change in our wayfinding skills, which may result from the technological advances 24 in navigational aids over the last few decades. 25 3 26 Introduction 27 Wayfinding; the ability to find one's way in an unfamiliar environment, has an outstanding 28 place among our cultural skills. The ability to find one's way in a complex environment is no 29 trivial feat. It is therefore not surprising that we find a high degree of variability in individuals' 30 ability and the strategies used and declines in normal aging [1], in neurodegenerative disease 31 [2] and with vestibular dysfunction [3,4]. These strategies have been broadly defined as route 32 strategies and orientation strategies [5,6]. The difference between these two strategies is 33 demonstrated in Figure 1. 34 35 Figure 1. Illustration of the two main wayfinding strategy types. Left: the orientation strategy, in 36 which individuals use spatial relations and global reference points such as the sun or cardinal directions to 37 navigate. Individuals that use this strategy often report having a 2D m...

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Section: ~~~~~~~~~ Table 3 About Here (Separate File) ~~~~~~~2mentioning

confidence: 99%

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confidence: 99%

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Who gets lost and why: A representative cross-sectional survey on sociodemographic and vestibular determinants of wayfinding strategies

Ulrich

Grill

Flanagin

2018

Preprint

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show abstract

“…Prevalence rates vary from 0.7% to 15%, although certain groups (e.g., those with congenital TORCH [toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus] infections, prematurity and/or hearing loss) are known to be at higher risk for vestibular dysfunctions . Moreover, recent studies suggest that the impact of vestibular dysfunction may be greater than previously thought and may not be limited to delayed (gross) motor development, but could also be accompanied by learning difficulties (e.g., reading, writing) or cognitive deficits (e.g., visuospatial orientation, attention). In young children (age < 6 years), both history taking and vestibular assessment are challenging, because children report vague symptoms lacking the appropriate vocabulary to describe their complaintsm, vestibular tests are not very child friendly, and the available equipment is not adapted to the pediatric population .…”

Section: Introductionmentioning

confidence: 99%

Vestibular assessment in the pediatric population

2018

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“…AS medication does not only have an overall effect on functioning, it is moreover known to extend cognitive decline . Interestingly, chronic VoD have also been posited as risk factors for cognitive decline, e.g., by a direct action on hippocampal structures and functions . Both effects might be explained by actions of the cholinergic system, because muscarinic and nicotinic receptors are highly expressed in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%