Cognitive deficits in schizophrenia on the WAIS-R NI sentence arrangement subtest

Abstract

Performance of participants diagnosed with schizophrenia on the Sentence Arrangement subtest of the WAIS-R NI and several tests sensitive to frontal lobe dysfunction was significantly poorer than that of manic depressive or control participants. Several measures of performance of patients diagnosed with schizophrenia on the WAIS-R NI Sentence Arrangement subtest appeared to support recent interpretations of the cognitive deficit seen in schizophrenia. These data represent the first demonstration of deficit performance by patients with schizophrenia on the Sentence Arrangement subtest. This is also supportive of the prediction that one of the areas whose activity may influence scores on this subtest is the prefrontal cortex. In addition, neither positive nor negative symptoms systematically correlated with the cognitive deficits reported despite specific predictions from the current literature.

The neurocognitive functioning in bipolar disorder: a systematic review of data

“…Irrespective of illness phase and symptom severity, the speed of mental processing in BD patients seems to be slower [ 34 , 43 – 45 , 59 , 70 – 87 ]. Moreover, it has been reported that the speed of mental processing is less affected in comparison to schizophrenia [ 38 , 40 , 61 , 88 ], although there are some data suggesting the presence of a similar degree of impairment between patients with BD and patients with schizophrenia [ 89 ]. On the other hand, it has been suggested that there were no significant differences between depressed BD patients, euthymic BD patients and healthy controls in psychomotor speed [ 90 ].…”

“…It has been suggested a severe impairment in executive functions except reasoning during all phases of BD [ 34 , 36 , 43 – 45 , 48 , 70 , 72 , 73 , 75 – 77 , 86 , 87 , 90 , 94 , 101 – 103 , 108 , 109 , 111 , 120 – 122 , 129 , 143 , 146 , 149 , 190 , 195 , 197 – 209 ] and early during the course of BD [ 93 ], but the deficit is less pronounced in comparison to schizophrenia [ 38 , 40 , 61 , 89 , 116 , 122 , 210 ]. However, at least a subgroup of patients is as severely impaired as patients with schizophrenia [ 153 , 211 , 212 ].…”