Cognitive Deficits in the THINC-Integrated Tool (THINC-it) Are Associated With Psychosocial Dysfunction in Patients With Major Depressive Disorder

Knight, Matthew J.; Fourrier, Célia; Lyrtzis, Ellen; Aboustate, Natalie; Sampson, Emma; Hori, Hikaru; Mills, Natalie; Baune, Bernhard T.

doi:10.4088/jcp.18m12472

Cited by 16 publications

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“…27 A recent study showed that the cognitive defects identified by THINC-it were correlated with overall and specific psychosocial defects, thus confirming the clinical value and utility of THINC-it as a cognitive screening tool for MDD patients. 28 The THINC-it is a self-administered tool which requires some instructions given to the subject who must be able to operate a computer independently. Objective and subjective methods are used to screen cognitive impairment of patients with depression, 8 including cognitive tests of attention, working memory, processing speed, executive function, and cognitive function of capturing subjective perception.…”

Section: Introductionmentioning

confidence: 99%

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Reliability and Validity of THINC-it in Evaluating Cognitive Function of Patients with Bipolar Depression

Zhang

Zhu

Lai

et al. 2020

NDT

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The THINC-integrated tool (THINC-it) as a brief screening tool can assesses cognitive impairment in patients with major depressive depression (MDD). Here, we aim to evaluate the reliability and validity of the THINC-it in a bipolar depression (BD-D) group in comparison with a healthy control (HC) group. Materials and Methods: Both groups were matched according to age, gender, years of education, and IQ. All participants completed the THINC-it test, including Spotter, Symbol Check, Codebreaker, Trails, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D). The concurrent validity and internal consistency of the THINC-it test were analyzed, and 30 healthy controls were randomly sampled to retest THINC-it to verify the reliability of the THINC-it retest. The correlation between THINC-it and Hamilton Depression Scale (HAMD-17) and Sheehan Disability Scale (SDS) was also analyzed. Results: Fifty-eight patients with BD-D and 61 HCs were included for final analysis. There were significant mean difference (MD) standard errors (SE) between two groups in PDQ-5-D, Spotter and Codebreaker (all P<0.01), Trails (P=0.015). There was no significant difference in Symbol Check (MD (SE)=−0.01 (0.18), P=0.938; 95% CI=−0.38 to 0.35). The Cronbach's α of PDQ-5-D was 0.640. The intraclass correlation coefficient (ICC) was between 0.440 and 0.757. The highest concurrent validity was PDQ-5-D (r=0.812, P<0.001). PDQ-5-D was positively correlated with HAMD-17 and SDS score (P<0.01). The objective test had no significant correlation with HAMD-17 and SDS scores (P>0.05). Conclusion: This study found that THINC-it can accurately present the cognitive impairment of patients with BD-D. It can be potentially applied in assessing the cognitive function of patients with BD-D although Symbol Check may not accurately reflect the level of cognitive function. The concurrent validity and retest reliability are lower than expected, we need to further increase the sample size to study.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reliability and Validity of THINC-it in Evaluating Cognitive Function of Patients with Bipolar Depression

Zhang

Zhu

Lai

et al. 2020

NDT

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“…Some studies have found significant associations between cognition and functioning in acute MDD, 11,28,29 while others have not. 12,13 Our study generally supports the body of knowledge that there is a relationship between baseline cognition and functioning in MDD populations.…”

Section: Discussionmentioning

confidence: 99%

Cognition and Its Association with Psychosocial and Occupational Functioning during Treatment with Escitalopram in Patients with Major Depressive Disorder: A CAN-BIND-1 Report: La Cognition Et Son Association Avec Le Fonctionnement Psychosocial Et Professionnel Durant Le Traitement Par Escitalopram Chez Des Patients Souffrant De Trouble Dépressif Majeur: Une Étude Can-Bind-1

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Objectives: Major depressive disorder (MDD) is associated with impairments in both cognition and functioning. However, whether cognitive deficits significantly contribute to impaired psychosocial and occupational functioning, independent of other depressive symptoms, is not well established. We examined the relationship between cognitive performance and functioning in depressed patients before and after antidepressant treatment using secondary data from the first Canadian Biomarker Integration Network in Depression-1 study. Methods: Cognition was assessed at baseline in unmedicated, depressed participants with MDD ( n = 207) using the Central Nervous System Vital Signs computerized battery, psychosocial functioning with the Sheehan Disability Scale (SDS), and occupational functioning with the Lam Employment Absence and Productivity Scale (LEAPS). Cognition ( n = 181), SDS ( n = 175), and LEAPS ( n = 118) were reassessed after participants received 8 weeks of open-label escitalopram monotherapy. A series of linear regressions were conducted to determine (1) whether cognitive functioning was associated with psychosocial and occupational functioning prior to treatment, after adjusting for overall depressive symptom severity and (2) whether changes in cognitive functioning after an 8-week treatment phase were associated with changes in psychosocial and occupational functioning, after adjusting for changes in overall symptom severity. Results: Baseline global cognitive functioning, after adjusting for depression symptom severity and demographic variables, was associated with the SDS work/study subscale (β = −0.17; P = 0.03) and LEAPS productivity subscale (β = −0.17; P = 0.05), but not SDS total (β = 0.19; P = 0.12) or LEAPS total (β = 0.41; P = 0.17) scores. Although LEAPS and SDS scores showed significant improvements after 8 weeks of treatment ( P < 0.001), there were no significant associations between changes in cognitive domain scores and functional improvements. Conclusion: Cognition was associated with occupational functioning at baseline, but changes in cognition were not associated with psychosocial or occupational functional improvements following escitalopram treatment. We recommend the use of more comprehensive functional assessments to determine the impact of cognitive change on functional outcomes in future research.

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“…MDD is diagnosed by the appearance of mood disturbances; however, a multitude of symptoms are often present, and there is accumulating evidence that symptomatic treatment for mood disturbances may be insufficient for the treatment of MDD 16–19. Cognitive dysfunction has been associated with psychosocial dysfunction and work impairment, including decreased work productivity and/or increased absenteeism 16,20–23. Evidence suggests that management of cognitive function may improve patient outcomes in MDD 16…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18][19] Cognitive dysfunction has been associated with psychosocial dysfunction and work impairment, including decreased work productivity and/or increased absenteeism. 16,[20][21][22][23] Evidence suggests that management of cognitive function may improve patient outcomes in MDD. 16 In recent years, guidelines have been generated and revised to standardize diagnostic tools for the diagnosis of psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Assessment of current clinical practices for major depression in Japan using a web-based questionnaire

Hori¹,

Yamato²

2019

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PurposeTo investigate the current clinical practice of Japanese physicians in the diagnosis and management of major depression (major depressive disorder [MDD]).Patients and methodsJapanese physicians specializing in psychiatry or psychosomatic medicine in the medical database of Nihon Ultmarc Inc. (Chuo-Ku, Tokyo, Japan), who had treated ≥30 patients with MDD in the past month were invited to complete a web-based questionnaire from January 15 to 29, 2018. The questionnaire was comprised of 28 questions pertaining to the physician’s background, the criteria and tools used to diagnose MDD during physician–patient consultation, and actual and preferred duration of physician–patient consultation. Responses were given as single answer numerical values or as multiple-choice answers.ResultsFrom the 518 physicians invited to participate, 340 completed questionnaires were analyzed. Respondents were predominantly male (90%), hospital based (73%), affiliated with the Department of Psychiatry (95%), and members of the Japanese Society of Psychiatry and Neurology (87%). The majority of physicians (84%) agreed that “improvement of cognitive dysfunction caused by major depression is an important factor for patients to return to work” was the most challenging aspect of MDD diagnosis and management. Moreover, 83% of physicians conducted psychological assessments using a cognition evaluation test with most of their patients at the time of MDD diagnosis; the most commonly used tool was the Hasegawa Dementia Scale-Revised. Both hospital-based physicians and general practitioners would prefer to have longer consultations with their patients.ConclusionPhysicians acknowledge the importance of the assessment and management of cognitive dysfunction in patients with MDD. However, most physicians would prefer to have longer consultation times with their patients for the diagnosis of MDD. In the future, it may be useful to introduce digital tools (eg, THINC-it®) for the initial screening of cognitive dysfunction.

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Cognitive Deficits in the THINC-Integrated Tool (THINC-it) Are Associated With Psychosocial Dysfunction in Patients With Major Depressive Disorder

Cited by 16 publications

References 0 publications

<p>Reliability and Validity of THINC-it in Evaluating Cognitive Function of Patients with Bipolar Depression</p>

<p>Reliability and Validity of THINC-it in Evaluating Cognitive Function of Patients with Bipolar Depression</p>

<p>Assessment of current clinical practices for major depression in Japan using a web-based questionnaire</p>

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