Cognitive Deterioration After Venlafaxine Overdose

García-Cabeza, Ignacio; Blas, Maria Martín Martín de; Epifanio, María Mar; Chávez, Manuel González de

doi:10.1016/j.jemermed.2009.04.059

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…Additionally, conclusions from previous research done by Ixchel Herrera and Ignacio et al on healthy subjects entail that the dopaminergic advancing agents like bupropion and sertraline possibly will improve vigilance and psychomotor performance in patients with depressive disorders ,also duloxetine improve the cognitive functions in depressed patients more significantly than placebo and the consequence be chiefly determined through enhancement in working memory ,moreover; venlafaxine showed better response in cognitive function than trazodone in randomized study of patients with depressive disorders [43,44]. De Jongh et al study founded enhancement in awareness but not memory in older depressed patients taken venlafaxine [45].…”

Section: Discussionmentioning

confidence: 99%

Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric Study

Al-Kuraishy¹,

Al-Gareeb²,

Albuhadilly³

et al. 2014

J Neurol Neurophysiol

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Extracts of ginkgo biloba have been broadly prescribed toward advance symptoms of cognitive dysfunction ranging in severity from mild memory loss to dementia also; in delaying the development of dementia; ginkgo biloba has been encouraged commercially as a smart medicine to augment the brain function of healthy people. Piracetam is a no tropic remedy correlated to inhibitory γ-aminobutyric acid (GABA) neurotransmitter. Piracetam may be the initial agent acting on cognitive function without sedation. Thirty subjects (30 males) arbitrarily choose as of medical college students. The contributors were allowable to perform mutually on the psychomotor performance device tester and the computerized n-back test (working memory task) to obtain knowledge from those tests sooner than the commencing of the examination. All psychometric response time and working memory test parameters calculated previous to the experimental research, so the identical volunteers considered as control and through four days of receiving the ginkgo biloba 60mg/day (trunature GSL),piracetam 800 mg/day (neutrophil) or both drugs so the enrolled participants divided into three groups .Group A take ginkgo biloba, group B take piracetam and group C take piracetam and ginkgo biloba.Piracetam significantly improve cognitive and working memory at all levels P<0.05 while it showed insignificant effects on psychometric reaction time parameters except it ameliorate the total reaction time (TRT) P <0.05. The differential effects of ginkgo biloba showed significant effects on psychometric reaction time and cognitive central Integrity P<0.05 and insignificant effects on working memory accuracy except at level І-Back where it produced significant effects P<0.05. Combined effects of ginko biloba and piracetam on psychomotor performances, cognitive function and working memory produced significant effects P <0.05.Conclusion: Combined effects of piracetam and ginkgo biloba produced more significant effects than either ginkgo biloba or piracetam alone on cognitive function and working memory.

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Section: Discussionmentioning

confidence: 99%

Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric Study

Al-Kuraishy¹,

Al-Gareeb²,

Albuhadilly³

et al. 2014

J Neurol Neurophysiol

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“…a severe attack of cardiac toxicity is often observed from the following day after taking an overdose of antidepressants), if there is extensive liver damage associated with paracetamol overdose and whether a specific therapy should be initiated (e.g. hemodialysis for an overdose of salicylates) (Christoph et al ., ; García‐Cabeza et al ., ; Jaeschke et al ., ; Schwaninger et al ., ; Ali et al ., ; Topoła et al ., ).…”

Section: Introductionmentioning

confidence: 98%

The application of capillary electrophoresis techniques in toxicological analysis

Sieradzka

Witt

Milnerowicz

2014

Biomedical Chromatography

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Capillary electrophoresis (CE) comprises a group of techniques used to separate chemical mixtures. Analytical separation is based on different electrophoretic mobilities, thereby allowing qualitative and quantitative evaluations to be made. The application of CE in medical science, especially in toxicological studies, is developing rapidly because of the short time required for analysis and its high sensitivity, selectivity and ability to determine substances of an acidic, alkaline and neutral character. This review focuses on the possibility of applying CE in toxicological analysis. Advances in different CE analyses and detection techniques connected with this method are described.

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“…Many venlafaxine poisonings in adults are documented in the form of case reports and reviews. [9][10][11][12][13][14][15][16][17][18][19][20] A number of adult overdoses (dosage range of 5-8.4 g) have resulted in serious toxicities.…”

Section: Introductionmentioning

confidence: 99%

An 11-year retrospective review of venlafaxine ingestion in children from the California Poison Control System

et al. 2015

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Venlafaxine is commonly used in the United States for approved and non-Food and Drug Administration–approved indications in adults. It is used off-label to treat children for psychiatric diagnoses. The aim of the study was to describe venlafaxine toxicities in children and to identify the venlafaxine dose per weight that correlates with toxicities. An 11-year retrospective study of venlafaxine ingestion in children was performed using the California Poison Control System (CPCS) database. Data was extracted from phone calls received by CPCS clinicians and follow-up phone calls made to assess the patient’s progress in a health-care setting. Inclusion criteria were venlafaxine ingestion cases reported to CPCS between January 2001 and December 2011, children aged 20 years and under, venlafaxine as the only ingested substance, managed in a health-care facility, and followed to a known outcome. Two hundred sixty-two cases met the study criteria. Common presentations included gastrointestinal (14.9%), altered mental status (13.7%), and tachycardia (13.4%). The majority of the cases resulted in no effect (51.5%) or minor effect (19.9%). The average estimated dose per weight was 18.3 mg/kg in all patients and 64.5 mg/kg in those experiencing moderate-to-severe adverse effects. Seizures occurred in only 4 of the 262 cases at doses ranging from 1500 to 7500 mg. Although the estimated dose per weight exceeded 10 mg/kg for the majority of the cases, only 12 cases resulted in moderate or severe outcomes. The majority of venlafaxine ingestion cases in children resulted in either no clinical effects or minor clinical effects.

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Cognitive Deterioration After Venlafaxine Overdose

Cited by 8 publications

References 27 publications

Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric Study

Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric Study

The application of capillary electrophoresis techniques in toxicological analysis

An 11-year retrospective review of venlafaxine ingestion in children from the California Poison Control System

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