Cognitive deterioration in schizophrenia: aging and cerebrovascular disease

Abstract

Today, cognitive dysfunction is accepted as a feature of schizophrenia. As the patients age, this dysfunction is higher and harder to evaluate due to the interaction among aging, other somatic diseases, psychoactive drugs, etc.

Assessment of 3-dimensional wisdom in schizophrenia: Associations with neuropsychological functions and physical and mental health

“…The importance of functional status in PwS cannot be understated. In addition to social cognitive deficits, neurocognitive performance is consistently and significantly impaired in severe mental illness (González-Pablos et al, 2018;Schaefer et al, 2013;Thompson et al, 2013), and these deficits predict multiple relevant functional outcomes, including quality of life (Mohamed et al, 2008), social problem solving (Green, Kern, Braff, & Mintz, 2000), occupational and economic capacity (Keefe and Harvey, 2012), community functioning (Green, Kern, & Heaton, 2004), interpersonal interactions (Milev et al, 2005), and instrumental skills (Green et al, 2000). Consequently, it is well established that neuropsychological performance is a crucial endpoint in PwS, and cognition is a prime target for interventions in this population (Keefe & Harvey, 2012).…”